Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Silencing and activation of embryonic globin gene expression.
Gordon D. Ginder,Rakesh Singal,Jane A. Little,Nancy J. Dempsey,Richard Ferris,Shou Zhen Wang +5 more
TL;DR: Mechanisms involved in stage‐specific embryonic β‐type globin gene silencing and activation are studied and it is shown that methylation of the exact CpG nucleotides that are methylated in normal adult erythroid cells in vivo is capable of blocking transcription of a transfected embryonic Globin gene promoter via binding of a methyl DNA binding protein in primary erystroid cells.
Journal ArticleDOI
Aberrant DNA methylation of genomic regions translocated in myeloid malignancies.
Craig E. Litz,Joan Etzell +1 more
TL;DR: The laboratory and others have gathered data supporting the hypothesis that aberrant DNA methylation may in some way predispose genomic regions to recombination in chronic myeloid leukemia and acute promyelocytic leukemia.
Journal ArticleDOI
Methylation Status of CpG Sites in the Mouse and Human CFTR Promoters
Erick Denamur,Farid F. Chehab +1 more
TL;DR: It is concluded that the CFTR promoter belongs to the class of CpG-rich promoters in which the associated C pG sites are not methylated in tissues and that an inverse correlation between methylation and CFTR expression can only be found in cell lines.
Journal ArticleDOI
Unique nucleolar dominance patterns in distant hybrid lineage derived from Megalobrama Amblycephala × Culter Alburnus.
TL;DR: Nucleolar dominance shows distinctive patterns in intergeneric hybrids of BSB × TC, and is not established in F1 hybrids and is random in F2 hybrids.
Journal Article
Nuclear methylation levels in normal and cancerous thyroid cells.
Adriana de Capoa,Claudio Grappelli,P. Volpino,Marco Bononi,Angelina Musolino,Antonio Ciardi,Antonino Cavallaro,V. Cangemi +7 more
TL;DR: The preliminary results suggest that the method of cell-by-cell detection of intranuclear methylation abnormalities may be a useful tool in early identification of thyroid cancer lesions.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.