Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Journal ArticleDOI
DNA methylation and carcinogenesis in digestive neoplasms.
TL;DR: Shortly after thepassage of the replication fork, a maintenanceDNA-MTase methylates CpG dinucleotides on thenewly synthesized strand, thereby recreating the spectrum of methyl groups that existed prior toreplication.
Journal ArticleDOI
Evaluation of methylated DNA binding protein-1 in mouse liver.
Paula S. Samiec,Jay I. Goodman +1 more
TL;DR: Electrophoretic mobility shift assay results indicate that MDBP-1 is present in mouse liver, and that the degree of methylation determines the strength of binding of MD BP-1 to DNA.
Journal ArticleDOI
High expression of S100A4 and endoglin is associated with metastatic disease in head and neck squamous cell carcinoma.
Marcos Vinícius Macedo de Oliveira,Carlos Alberto de Carvalho Fraga,Lucas Oliveira Barros,Camila Santos Pereira,Sérgio Henrique Sousa Santos,John R. Basile,Ricardo Santiago Gomez,André Luiz Sena Guimarães,Alfredo Maurício Batista De-Paula +8 more
TL;DR: Results showed that S100A4 methylation status failed to demonstrate association with cervical metastasis and other clinicopathological factors related to HNSCC, and molecular disturbances in S 100A4 and endoglin expression might regulate the formation of cervical metastases in HNS CC.
Journal ArticleDOI
The herpesvirus saimiri ORF 73 regulatory region provides long-term transgene expression in human carcinoma cell lines.
TL;DR: It is demonstrated, utilizing transient transfection assays, that the ORF 73 regulatory region can provide transgene expression in a variety of human carcinoma cell lines, although levels of transGene expression are not as high as achieved under the control of heterologous promoters such as the IE hCMV promoter.
Journal ArticleDOI
Structure, DNA content and DNA methylation of synergids during ovule development in Malus domestica Borkh
A. M. Tagliasacchi,Andrea Andreucci,Enrico Giraldi,C. Felici,F. Ruberti,Laura Maria Costantina Forino +5 more
TL;DR: DNA content and DNA methylation of synergids of Malus domestica Borkh have been evaluated in two different stages before fertilization, supporting the assumption of a preprogramming for the degeneration of one of the two cells.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.