Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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The histone acetyltransferase Dmel\TIP60 Is essential for multicellular development in Drosophila
TL;DR: In this paper, the first isolation and developmental characterization of a Drosophila HAT gene (Dmel\TIP60) was reported, which is the homolog of the human TIP60.
Journal ArticleDOI
Quantitative investigation of the effects of DNA modifications and protein mutations on MeCP2-MBD-DNA interactions.
TL;DR: In this article , molecular dynamics simulations were used to investigate the underlying mechanisms behind changes due to different modifications of DNA and MBD mutations, and the results showed that MBD has the strongest binding ability for mCDNA, followed by caC, hmC, and fCDNA with the weakest binding ability observed for CDNA.
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Characterization of upstream sequences of the LIM2 gene that bind developmentally regulated and lens-specific proteins
Heng Hsu,Robert L. Church +1 more
TL;DR: In this paper, the second most abundant lens fiber cell intrinsic membrane protein is MP19, which probably is involved with lens cell communication and relates with cataractogenesis, and the aim of this research is to characterize upstream sequences of the MP19 (also called LIM2) gene that bind developmentally regulated and lens-specific proteins.
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DNA Methylation as a Biomarker for Monitoring Disease Outcome in Patients with Hypovitaminosis and Neurological Disorders
Olaia Martínez-Iglesias,Vinogran Naidoo,Lola Corzo,Rocío Pego,S Seoane,Susana Rodríguez,M. Alcaraz,Adriana Muniz,Natalia Cacabelos,Ramón Cacabelos +9 more
TL;DR: In this paper , differences in global DNA methylation (5mC) levels in serum samples from patients during the initial-and the follow-up visits were examined, revealing that 5mC has a diagnostic value as a biomarker across different pathologies.
The role of topoisomerase Ila and /I in drug resistance
TL;DR: An understanding of the normal role of the enzyme and its regulation should contribute to explaining differential tumour sensitivities and methodologies to overcome resistance.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.