Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Genome-wide DNA methylation and transcriptome analyses reveal important epigenetic genes associated with Valgus-varus deformity in broilers.
Yanhe Ma,C. Cai,Jianzeng Li,Lujie Zhang,R. Jiang,Yanhua Zhang,Yadong Tian,Xiangtao Kang,Ruili Han +8 more
TL;DR: In this article , the knee cartilage of 35-day-old VVD and normal broilers was sequenced by whole-genome bisulphite sequencing (WGBS).
Book ChapterDOI
Assessment of Risk for Hereditary Retinoblastoma
Thaddeus P. Dryja,Abigail K. Alt +1 more
Journal ArticleDOI
Natural Bioactive Products as Epigenetic Modulators for Treating Neurodegenerative Disorders
TL;DR: In this paper , the use of natural products as epidrugs to treat neurodegenerative disorders (NDDs) has been discussed in order to explore the epigenetic effects and benefits of functional foods and natural bioproducts.
Book ChapterDOI
Pluripotent Stem Cell Epigenetics During Development and Cancer
TL;DR: Recent results of the laboratory on the expression of two imprinted genes, U2af1-rs1 and H19, in normal and pluripotent male germinal cells and in embryonic stem cell after induction of differentiation and apoptosis by retinoic acid treatments can shed new light for a better understanding of testis embryonal carcinoma biology.
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.