Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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The effect of nutrition during early life on the epigenetic regulation of transcription and implications for human diseases.
TL;DR: The environmental regulation of epigenetic processes is a central component in the developmental origins of non-communicable diseases and understanding of these processes is critical both for the identification of individuals at risk and for the development of new intervention strategies.
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Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer.
TL;DR: The promoter hypermethylation status of PRSS3 was determined in a case series study of primary NSCLC, and methylation of this gene was found to be common, occurring in 53% (86 of 166) of tumors examined.
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Methylation of serum insulin-like growth factor-binding protein 7 promoter in hepatitis B virus-associated hepatocellular carcinoma.
TL;DR: The results suggest that methylation of the serum IGFBP7 gene promoter may serve as a useful noninvasive biomarker for HCC diagnosis.
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In vitro methylation of the human O6-methylguanine-DNA methyltransferase promoter reduces transcription.
TL;DR: The effect of in vitro methylation of the MGMT promoter in a reporter gene construct transfected into cultured human cells suppressed the activity of the promoter, although the effect was not absolute.
Journal ArticleDOI
N 6-methyladenine DNA modification in the unicellular eukaryotic organism Tetrahymena thermophila
TL;DR: The features and potential functions of 6mA in Tetrahymena thermophila and other ciliates, and the major findings and contributions of the TetrahYmena model in studies of 6AMA methylation are summarized.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.