Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Evaluation of methylation degree from formalin-fixed paraffin-embedded DNA extract by field-amplified sample injection capillary electrophoresis with UV detection.
Angelo Zinellu,Salvatore Sotgia,Valentina De Murtas,Paolo Cossu-Rocca,Maria Rosaria De Miglio,Maria Rosaria Muroni,Antonica Mura,Maria Gabriela Uras,M Contini,Luca Deiana,Ciriaco Carru +10 more
TL;DR: The first capillary electrophoresis method able to measure global methylation in formalin-fixed, paraffin-embedded (FFPE) DNA extracts is developed, useful for large-scale applications to determine the implications of genomic DNA methylation levels in tumorigenesis.
Journal ArticleDOI
Biological and biochemical modulation of DNA methylation.
Raymond Lo,Rosanna Weksberg +1 more
TL;DR: This review will focus onDNA methylation and DNA methyltransferases with emphasis on how biological and biochemical factors such as histone modifications and noncoding RNAs might play a role in modulating DNA methylation.
Journal ArticleDOI
Sickle Cell Disease: Present and Future Treatment
TL;DR: This review will briefly highlight the major aspects of the conventional treatment of sickle cell disease, address the present use of hydroxyurea in more depth, and succinctly preview what the near-term future of treatment may bring.
Journal ArticleDOI
GFAP gene methylation in different neural cell types from rat brain.
TL;DR: The methylation status of one of the seven CG sites of the ‘neuroectoderm‐specific domain’ was analyzed and it was found that the −1176 site is highly demethylated in astroglial, oligodendroglials and neuronal cells, but heavily methylated in microglial and fibroblast cells.
Journal ArticleDOI
Gene control of flowering time in higher plants
TL;DR: A lot of achievements have been made recently in gene control for the determination of flowering time, and some new advances of such researches related to the work and the interesting field are reviewed.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.