Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1
Reid Huber,R. Scott Hansen,Maria Strazzullo,Gina Pengue,Richard Mazzarella,Michele D'Urso,David Schlessinger,Giuseppe Pilia,Stanley M. Gartler,Maurizio D'Esposito +9 more
TL;DR: Examination of SYBL1, a housekeeping gene in the Xq pseudoautosomal region, and GPC3, a tissue-specific gene in Xq26 that is implicated in the etiology of the Simpson-Golabi-Behmel overgrowth syndrome, suggest that all CpG islands on Xq, including the pseudoautous region, are subject to X inactivation-induced methylation.
Journal ArticleDOI
H19 in normal development and neoplasia.
Leendert H. J. Looijenga,Annemieke J.M.H. Verkerk,Nathan de Groot,Abraham Hochberg,J. Wolter Oosterhuis +4 more
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Genomic Organization and the 5′ Flanking Region of the γ Subunit of the Human Amiloride-sensitive Epithelial Sodium Channel *
TL;DR: The structure of the human γENaC gene is determined and the first description of the structural organization and the 5′ flanking region of a member of the epithelial sodium channel complex is described.
Journal ArticleDOI
Cytosine methylation of an Sp1 site contributes to organ-specific and cell-specific regulation of expression of the lung epithelial gene t1alpha.
TL;DR: It is reported that T1alpha is methylated at a key Sp1 site in the proximal promoter in cells and organs, including brain, where no gene expression is detectable, and concluded that cytosine methylation has a role in the complex expression patterns of this gene in intact animals and primary cells.
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2’-Deoxy-N4-[2-(4-nitrophenyl) ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1
Hyang-Min Byun,Si Ho Choi,Peter W. Laird,B. Trinh,Maqbool A. Siddiqui,Victor E. Marquez,Allen S. Yang +6 more
TL;DR: Differences between decitabine and NPEOC-DAC are dependent on the cleavage of the carboxylester bond, and could be potentially exploited pharmacologically.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.