Journal ArticleDOI
The essentials of DNA methylation.
Reads0
Chats0
About:
This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
More filters
Journal ArticleDOI
Correlation of Deregulated Like-Acetylglucosaminyl Transferase and Aberrant α-Dystroglycan Expression With Human Tongue Cancer Metastasis
TL;DR: Aberrant α-DG expression and glycosylation were attributed at least in part to the abnormal epigenetic modification of LARGE, especially the hypermethylation of its promoter.
Journal ArticleDOI
The epigenetics of keloids.
Andrew W. Stevenson,Zhenjun Deng,Amira Allahham,Cecilia M Prêle,Fiona M. Wood,Fiona M. Wood,Mark W. Fear +6 more
TL;DR: Keloid scarring is a fibroproliferative disorder of the skin with unknown pathophysiology, characterised by fibrotic tissue that extends beyond the boundaries of the original wound as discussed by the authors.
Journal ArticleDOI
Successful application of human-based methyl capture sequencing for methylome analysis in non-human primate models.
Ja-Rang Lee,Dong-Sung Ryu,Sang-Je Park,Se-Hee Choe,Se-Hee Choe,Hyeon-Mu Cho,Hyeon-Mu Cho,Sang-Rae Lee,Sang-Rae Lee,Sun-Uk Kim,Sun-Uk Kim,Young-Hyun Kim,Young-Hyun Kim,Jae-Won Huh,Jae-Won Huh +14 more
TL;DR: Use of human-based MC-seq methods provides an attractive, cost-effective approach for the methylome profiling of non-human primates at the single-base resolution level.
Journal ArticleDOI
5-methylcytosine at HpaII sites in p53 is not hypermutable after UVC irradiation.
Paola Monti,Alberto Inga,Gina B. Scott,Anna Aprile,Paola Campomenosi,Paola Menichini,Laura Ottaggio,Silvia Viaggi,Angelo Abbondandolo,Philip A. Burns,Gilberto Fronza +10 more
TL;DR: It is proposed that position 742 is a hot spot in NMSC either because of mutagenic events at 5mC caused by other UV components of solarlight and/or because not all the NMSCs are directly correlated with UV mutagenesis but may have a "spontaneous" origin.
References
More filters
Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.