Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Environmental challenge, epigenetic plasticity and the induction of altered phenotypes in mammals.
TL;DR: Overall, current findings indicate that epigenetic processes may play an important role in determining disease risk, but there is a lack of studies that demonstrate causal links between epigenetic change and tissue function.
Journal ArticleDOI
DNA methylation in ciliates: implications in differentiation processes.
TL;DR: Reports on DNA methylation in ciliated protozoa are reviewed, emphasizing its implications in cell differentiation processes and a comparative analysis with other similar microbial eukaryotic differentiation processes is carried out.
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Location of the S-adenosyl-L-methionine binding region of the vaccinia virus mRNA (guanine-7-)methyltransferase.
Meghan A. Higman,Edward G. Niles +1 more
TL;DR: Higman et al. as discussed by the authors showed that the mRNA (guanine-7-) methyltransferase activity of the heterodimeric vaccinia virus mRNA capping enzyme was enhanced 30- to 50-fold by the association of the small subunit, D12L.
Journal ArticleDOI
Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells.
Norishige Yamada,Yukari Nishida,Seiya Yokoyama,Hideaki Tsutsumida,Izumi Houjou,Sho Kitamoto,Masamichi Goto,Michiyo Higashi,Suguru Yonezawa +8 more
TL;DR: It is shown that the DNA methylation pattern is intimately correlated with MUC5AC expression in ten cancer cell lines (breast, lung, pancreas, and colon) and regulated by CpG methylation and histone H3-K9 modification of the M UC5AC promoter distal region, but not by miRNAs.
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Common genomic structure for the Lepidoptera cadherin-like genes.
Yolanda Bel,Baltasar Escriche +1 more
TL;DR: In silico analysis of the protein products of these genes showed a common structure and grouped these proteins into the protocadherin family and pointed out a highly conserved structure that indicates that these genes are orthologous.
References
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.