Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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DNA methylation signatures of breast cancer in peripheral T-cells.
Surabhi Parashar,David Cheishvili,Niaz Mahmood,Ani Arakelian,Imrana Tanvir,Haseeb Ahmed Khan,Richard Kremer,Catalin Mihalcioiu,Moshe Szyf,Shafaat A. Rabbani +9 more
TL;DR: Results from the current study provide for the first-time a potential role of DNA methylation changes in peripheral T cells in PCa and may allow for early intervention and stratification of patients into different prognostic groups to reduce PCa associated morbidity from repeat invasive prostate biopsies.
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Comprehensive Epigenetic Analysis Using Oral Rinse Samples: A Pilot Study
Takanobu Kusumoto,Tomofumi Hamada,Norishige Yamada,Satoshi Nagata,Yuji Kanmura,Izumi Houjou,Yoshiaki Kamikawa,Suguru Yonezawa,Kazumasa Sugihara +8 more
TL;DR: The present study showed for the first time that chromatin modifications can be analyzed using oral rinse samples by chromatin immunoprecipitation analysis, and evaluated the contribution of histone modifications for carcinogenesis of oral squamous cell carcinoma.
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High-Risk Myelodysplastic Syndromes and Hypermethylation of the p15Ink4B Gene
TL;DR: In this article, the authors investigated the methylation status of the p15INK4B gene in myelodysplastic syndrome (MDS) and found that it is also frequently hypermethylated at the promoter region located at the 5'-CpG island of exon 1.
Journal ArticleDOI
Epigenetic, histopathological and transcriptomic effects following exposure to depleted uranium in adult zebrafish and their progeny
Kewin Gombeau,Jean-Paul Bourdineaud,Jean-Luc Ravanat,Olivier Armant,Virginie Camilleri,Isabelle Cavalie,Magali Floriani,Christelle Adam-Guillermin +7 more
TL;DR: The extreme sensitivity of zebrafish embryos to DU transmitted through the oocyte by exposed females is revealed, with levels seven times higher than those measured in the control embryos, but in larvae 96h post-fertilisation (hpf), uranium concentration had already returned to that of the control larvae.
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Somatic excision of the Ac transposable element in transgenic Arabidopsis thaliana after 5-azacytidine treatment
TL;DR: These results may represent demethylation in few cells during development which may be sufficient to reactivate in these cells the expression of the nos and Ac transposase transgenes, the latter promoting Ac transposition in somatic cells.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.