Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Book ChapterDOI
Modulating Epigenetic Modification Enzymes Through Relevant Epidrugs as a Timely Strategy in Anticancer Therapy
TL;DR: The effect of histone methylation on gene expression depends on the site and degree of this epigenetic mark (Greer and Shi 2012) as discussed by the authors, which is the only modification that is methylation.
DissertationDOI
Estudo do perfil de expressão gênica na distrofia muscular fácio-escápulo-umeral (FSH)
Original article Inactivation of p16 by CpG hypermethylation in renal cell carcinoma
Marta Vidaurreta,M. Luisa Maestro,M. Teresa Sanz-Casla,C. Maestro,Sara Rafael,Silvia Veganzones,Jesús Moreno,Julia Blanco,Angel Silmi,Manuel Arroyo +9 more
TL;DR: Through multivariate analysis of overall survival, gene methylation was found to have independent prognostic value: the absence of alteration confers an undefined risk of death in these patients.
Dna methylation analysis in rhabdomyosarcoma
TL;DR: It is demonstrated that GADD45G and NELL1 could be novel potential biomarkers in RMS and it is evidenced that the DNA methylation pattern in R MS could be interesting for new therapeutic strategies.
DNA methylation and silencing of gene expression role in pathogenesis of systemic lupus erythematosus
TL;DR: This review summerise the current understanding of aberrant DNA methylation in T cells and consequently altered gene expression in SLE and summarized the alterations in ERK (Ras-MAPK) signaling pathway and overexpression of LFA-1 caused by certain drugs contributing to the development of manifestations of the disease.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.