Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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A model for systemic lupus erythematosus based on chromatin disruption by polyamines
TL;DR: It is hypothesized that some autoimmune disorders, such as systemic lupus erythematosus, result in part from overexpression of polyamines which leads to disruption of chromatin structure which facilitates transcription at previously sequestered sites.
Journal ArticleDOI
Tet1-mediated DNA demethylation involves in neuron damage induced by bilirubin in vitro.
TL;DR: Quantitative real-time PCR and western blot analysis showed that UCB can inhibit Tet1 and Klotho expression in cultured neuronal cells at both the mRNA and protein level, respectively.
Journal ArticleDOI
Cloning and characterization of the SIL promoter.
TL;DR: The cloned and sequenced the human SIL promoter, cloned a murine homolog, found the sequence to be highly conserved, and defined a minimal promoter region, which provides an important tool for the study of both the SIL gene expression as well as the role of the SIL promoter in leukemogenesis.
Journal ArticleDOI
Can the rDNA methylation pattern be used as a marker for Alzheimer's disease?
Márcia Aparecida Sperança,Lisandra Mesquita Batista,Ricardo da Silva Lourenço,Wagner Malagó Tavares,Paulo Henrique Ferreira Bertolucci,Valdeci de Oliveira Santos Rigolin,Spencer Luiz Marques Payão,Marília de Arruda Cardoso Smith +7 more
TL;DR: Differential methylation activity of the human rDNA in Alzheimer's disease patients has been demonstrated by classic cytogenetic tools, indicating a decrease in rRNA gene expression.
Dissertation
Gene expression in human preimplantation embryos.
TL;DR: Gene transcription during early embryonic development of the human has been investigated using single cell RT-PCR techniques for several house-keeping genes and a positive correlation between the presence of a CpG island in a gene and its expression in early embryos is revealed.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.