Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Gene rearrangements in human T cells.
TL;DR: One of the most basal requirements of the immune system is that it must be capable of specifically recognizing and responding to foreign antigens, while remaining indifferent to self-components.
Genetic (in)stability in tomato
TL;DR: It is proposed that mechanisms which are known to underlie genetic instability in other organisms, have a role in the unstable expression of yv and sulfurea and the hybridization of tomato DNA to alien transposable element probes emphasize the stability of transposability element-like sequences in the tomato genome.
Journal ArticleDOI
Società Botanica Italiana: Lavori Presentati Alla Riunione Scientifica Annuale Dei Gruppi di Lavoro Per la Citologia Eperil Differenziamento Ele Colture Dei Tessuti Ferrara, 20–22 Giugno 1994
Posted ContentDOI
DNA methylation and gene expression dynamics during cotton ovule and fiber development
TL;DR: It is shown that inhibiting DNA methylation impairs fiber development and could act as a double-lock feedback mechanism to regulate TE and gene expression, which could be translated into genomic and biotechnological improvement of agronomic traits.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.