Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Reverse transcriptase: Mediator of genomic plasticity
Jürgen Brosius,Henri Tiedge +1 more
TL;DR: Retroposons, with their unique properties and actions, form the molecular basis of important evolutionary concepts, such as exaptation and punctuated equilibrium, and can be considered as a major pacemaker for evolution (including speciation).
Journal ArticleDOI
Pollutants inducing epigenetic changes and diseases
Vivek Jagadeesan Sharavanan,Muthusaravanan Sivaramakrishnan,N. Sivarajasekar,N. Senthilrani,Ram Kothandan,Nirajan Dhakal,Selvaraju Sivamani,Pau Loke Show,Md. Rabiul Awual,Mu. Naushad +9 more
TL;DR: Mechanisms by which pollutants disrupt epigenetic factors are reviewed, focusing on the impact of arsenic, cadmium, nickel, mercury, benzene, bisphenol A, dioxin, hexahydro-1,3,5-trinitro-4-triazine and diethylstilbestrol.
Journal ArticleDOI
DNA Methylation as a Target for Drug Design
TL;DR: The mutagenicity of 5-Methylcytosine (5mC) and the role of promoter hypermethylation in gene silencing, particularly in cancer, suggest a clinical significance for the design of novel DNA methylation inhibitors which may be utilized to reverse the effects ofDNA methylation.
Journal ArticleDOI
Genetic vaccination: the advantages of going naked.
Vipin Kumar,Eli E. Sercarz +1 more
TL;DR: Manipulating the immune system with DNA vaccines shows promise for protecting against pathogens and suppressing autoimmune disease and improving the quality of existing vaccines.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.