Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Depleted uranium induces sex- and tissue-specific methylation patterns in adult zebrafish
Kewin Gombeau,Sandrine Pereira,Jean-Luc Ravanat,Virginie Camilleri,Isabelle Cavalie,Jean-Paul Bourdineaud,Christelle Adam-Guillermin +6 more
TL;DR: The sex- and tissue-specific epigenetic changes that occur in a nonhuman organism after exposure to environmentally relevant concentrations of uranium, which could induce transgenerational epigenetic effects are reported for the first time.
Journal ArticleDOI
Analysis of a brain-specific isozyme. Expression and chromatin structure of the rat aldolase C gene and transgenes.
TL;DR: It is proposed that the chromatin structure around the aldolase C promoter is accessible in fetal tissues, then remains open in the adult brain, where the gene is very active, as well as in tissues in which it is practically inactive.
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5‑Azacytidine inhibits human rhabdomyosarcoma cell growth by downregulating insulin‑like growth factor 2 expression and reactivating the H19 gene product miR‑675, which negatively affects insulin‑like growth factors and insulin signaling
Maciej Tarnowski,Marta Tkacz,Michał Czerewaty,Agata Poniewierska-Baran,Katarzyna Grymula,Mariusz Z. Ratajczak +5 more
TL;DR: AzaC-mediated demethylation of the DMR at the IGF2‑H19 locus resulted in a decrease in RMS proliferation due to downregulation of IGF2 and, IGF1R expression in an miR‑675‑dependent manner, which confirms the crucial role of LOI at the insulin-like growth factor 1 receptor in the pathogenesis of RMS.
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Potential role of folate in pre-eclampsia
TL;DR: The present review highlights associations between folate deficiency and certain biomarkers observed in various tissues of women at risk of pre-eclampsia.
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Regulation of transcription of the glutathione S-transferase P1 gene by methylation of the minimal promoter in human leukemia cells
TL;DR: In vitro SssI methylation of the minimal GSTP1 promoter, which led to the silencing of the promoter activity in transient transfection assays in expressing K562 as well as in non-expressing Raji cells, indicate thatmethylation of CpG sites of the basal promoter is an essential mechanism in the control of GSTP 1 gene expression in human leukemia.
References
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.