Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression.
Chika Kusui,Tadashi Kimura,Kazuhide Ogita,Hitomi Nakamura,Yoko Matsumura,Masayasu Koyama,Chihiro Azuma,Yuji Murata +7 more
TL;DR: The results indicate that the methylation of the CpG island in the human OTR gene promoter suppressed its transcription at least in liver and may regulate tissue specific gene expression among organs.
Journal Article
Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression.
TL;DR: The first evidence that ER gene is transcriptionally inactivated by DNA methylation in prostate cancer is presented, and the data suggest that ER may be involved in the pathogenesis of prostate cancer, as well as BPH.
Journal ArticleDOI
Modulation of DNMT1 activity by ADP-ribose polymers.
TL;DR: It is shown that DNMT1 is able to bind long and branched ADP-ribose polymers in a noncovalent way and suggested that this complex is catalytically inefficient in DNA methylation.
Journal Article
Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis.
TL;DR: It is concluded that CpG-ODNs trigger extramedullary hemopoiesis, and that this finding could be of therapeutic relevance in myelosuppression.
Journal ArticleDOI
Epigenetic and developmental regulation in plant polyploids.
Qingxin Song,Z. Jeffrey Chen +1 more
TL;DR: Development regulation and epigenetic changes including DNA methylation and histone modifications in polyploids are reviewed, which suggest that epigenetic modifications can alter homoeologous gene expression and reprogram gene expression networks, which allows polyploidy to establish new cytotypes, grow vigorously and promote adaptation in local environments.
References
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.