Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Dissertation
Structure of schizosaccharomyces pombe DNA in mouse cells
TL;DR: Adoption of the host nucleosomal repeat by introduced sequences was found to be a general phenomenon, independent of the structure of introduced DNA, which showed that nucleosome structure was dependent upon the host repertoire of historic and accessory factors and not on the underlying DNA sequence.
Book ChapterDOI
Molecular and Pathological Characterization of Human Tumors
TL;DR: It is hoped that the new molecular techniques will help provide a molecular classification that is more robust and clinically useful.
Book ChapterDOI
Developmental Origins of Adult Disease: Impacts of Exposure to Environmental Toxicants
TL;DR: This chapter provides an overview of the current state of knowledge of the association of known prenatal toxicants in humans and/or experimental animals, namely arsenic, bisphenol A, diethylstilbestrol, and cigarette smoke, with latent disease development.
Journal ArticleDOI
Modular affinity-labeling of the cytosine demethylation base elements in DNA.
TL;DR: A modular method for labeling base modifications in DNA to recognize all four bases involved in demethylation is extended and differential insertion of a single affinity tag at the precise position of target elements and subsequent repair of the nicked phosphate backbone that remains following the procedure are demonstrated.
Journal ArticleDOI
The Role of DNA Methylation in Stroke Recovery
TL;DR: The role of DNA methylation in neuroprotection and neuronal recovery after stroke is summarized according to the current knowledge regarding the effects ofDNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.