Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Book ChapterDOI
Methylated DNA-binding proteins and chromatin structure
TL;DR: These phenomena imply that the stable assembly of DNA into different types of higher order chromatin structures can be a major determinant of genome activity.
Book ChapterDOI
Gut dysbiosis and its epigenomic impact on disease
TL;DR: Normal microbiome development as well as common mechanisms of dysbiosis in the context of pathophysiology are reviewed, suggesting treatments that directly manipulate the microbiome composition are not currently available.
Dissertation
Das Cd-induzierbare crp-Gen aus dem terrestrischen Oligochaeten Enchytraeus: Genomische Organisation und Bedeutung für die Cd-Detoxifizierung
TL;DR: In this paper, Enchytraeus exprimierted enchtraeus eine mRNA, which is a CRP-Protein kodierted by Enchreiche buchholzi.
Molecular genetics of early liver development
TL;DR: The control of liver development was originally defined by classical histology and tissue transplantation studies twenty to thirty years ago but in the past ten years, molecular biology studies have revealed numerous transcription factors important for adult liver differentiation.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.