Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
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Dissertation
Epigenetic regulation of enos gene expression
TL;DR: Functional expression assays revealed that the methylation-mediated trancriptional repression of the eNOS gene involves an indirect mechanism, implicating the involvement of both the preferential assembly of methylated DNA into an inactive chromatin snucture and the binding of methyl-CpG-binding proteins (MeCP-2).
Journal ArticleDOI
Screening for herbal medicines that affect ZIC1 gene methylation in colorectal cancer
TL;DR: Of the herbal medicines studied, V. rotundifolia is the best candidate for the demethylation of ZIC1 and other herbal medicines represent novel therapeutic avenues that can be utilized for the prevention or treatment of colorectal cancer.
Book ChapterDOI
Parp and Epigenetic Regulation
TL;DR: The hypothesis is posited that inhibition of the poly(ADP-ribosyl)ation process in the cell may be responsible for the anomalous hypermethylation of tumor suppressor gene promoters during tumorigenesis.
Journal ArticleDOI
Gene-specific changes of DNA methylation accompany differentiation of the slime mold Physarum polycephalum.
Radoslaw Magiera,Jan Fronk +1 more
TL;DR: The mechanisms whereby DNA methylation influences transcription are only beginning to be understood (Boyes and Bird, 1992), while the causes of differential gene methylation remain unknown (see Szyf, 1991 for hypotheses).
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.