Journal ArticleDOI
The essentials of DNA methylation.
Reads0
Chats0
About:
This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
More filters
Book ChapterDOI
A coordinated interplay: Proteins with multiple functions in DNA replication, DNA repair, cell cycle/ checkpoint control, and transcription
TL;DR: The "common enzyme-different pathway strategy" is fascinating from several points of view: first, it might guarantee that these events are coordinated; second, it can be viewed from an evolutionary angle; and third, this strategy might provide cells with backup mechanisms for essential physiological tasks.
Journal ArticleDOI
Genomic footprinting and sequencing of human beta-globin locus. Tissue specificity and cell line artifact
TL;DR: Although the patterns of nuclear factor-DNA interaction in vivo at the NF-E2/AP1, GATA-1, and GT-I motifs of 5'HS-2 enhancer in adult erythroblasts are similar to those in K562 cells, it is identified a previously undetected factor-binding motif of5' HS-2 that is protected only in the adult eries, suggesting an important regulatory role of this element in human beta globin gene transcription in
Book ChapterDOI
Biological implications of the mechanism of action of human DNA (cytosine-5)methyltransferase.
TL;DR: This chapter describes the enzymological boundaries of the phenomenon of human deoxyribonucleic acid (DNA) methylation, set by the specificity and mechanism of action of the human DNA methyltransferase(s), from both bacterial and human sources.
Journal ArticleDOI
Differential Regulation of Methionine Adenosyltransferase in Superantigen and Mitogen Stimulated Human T Lymphocytes
TL;DR: The data suggest that the β subunit of MAT II, which has no catalytic activity, may be a regulatory subunit that imparts a lowerK m for l-Met but increases the sensitivity to feedback inhibition by AdoMet.
References
More filters
Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.