Journal ArticleDOI
The essentials of DNA methylation.
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This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
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Methylation altered DNA sequences as markers associated with human cancer
Isabel D.C. Markl,Peter A. Jones,Yoshitaka Tomigahara,Gangning Liang,Hualin Fu,Jonathan Cheng +5 more
TL;DR: In this paper, the authors disclosed 103 novel methylation-altered DNA sequences (marker sequences) that have distinct methylation patterns in cancer, compared to normal tissue, and these sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer.
Journal ArticleDOI
Qualitatively Predicting Acetylation and Methylation Areas in DNA Sequences
TL;DR: This paper introduces a computational approach to the qualitative prediction of nucleosome occupancy, acetylation, and methylation areas in DNA sequences using support vector machines to discriminate between DNA areas with high and low relative occupancy and rank k-gram features based on their support for these DNA modifications.
Journal ArticleDOI
Sickle Cell Anemia and Fetal Hemoglobin
TL;DR: The authors are able to increase fetal hemoglobin levels by pharmacologic means and should know shortly if this is associated with clinical benefit.
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Structural characterization of the mouse Foxf1a gene.
TL;DR: It is shown that the proximal 5' flanking sequence and exon 1 of the endogenous gene are highly methylated in Hepa 1-6 cells but not in SVEC4-10 cells, suggesting that DNA methylation but not cell-specific transcription factor(s) regulates cell specificity of gene expression in these cultured cells.
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DNA methylation changes detected by methylation-sensitive amplified polymorphism in the Pacific oyster (Crassostrea gigas) in response to salinity stress
TL;DR: In this study, fluorescent-labeled methylation-sensitive amplified polymorphism (F-MSAP) analysis was used to investigate the frequency and variation of DNA methylation in C. gigas under different salinity and time, and showed that total methylation level was generally on a downward trend.
References
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Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
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Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
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DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.