Journal ArticleDOI
The essentials of DNA methylation.
Reads0
Chats0
About:
This article is published in Cell.The article was published on 1992-07-10. It has received 928 citations till now. The article focuses on the topics: DNA methylation & Methylation.read more
Citations
More filters
Journal ArticleDOI
The vegetarian lifestyle and DNA methylation.
Jürgen Geisel,Heike Schorr,Marion Bodis,Sonia Isber,Ulrich Hübner,Jean-Pierre Knapp,Rima Obeid,Wolfgang Herrmann +7 more
TL;DR: The results indicate that the degree of methylation does not depend on the supply of methyl groups and that the reverse generation of SAH has no influence, and three observations indicate that DNA methylation could be diminished by a vegetarian lifestyle.
Journal ArticleDOI
Molecular Cloning, Characterization, and Promoter Analysis of the Mouse Crp2/SmLim Gene PREFERENTIAL EXPRESSION OF ITS PROMOTER IN THE VASCULAR SMOOTH MUSCLE CELLS OF TRANSGENIC MICE
Shaw-Fang Yet,Sara C. Folta,Mukesh K. Jain,Chung-Ming Hsieh,Koji Maemura,Matthew D. Layne,Dorothy Zhang,Pooja B. Marria,Masao Yoshizumi,Michael T. Chin,Mark A. Perrella,Mark A. Perrella,Mu-En Lee +12 more
TL;DR: In vivo, the 5-kilobase fragment directed high level expression of the lacZ reporter gene preferentially in the VSMC of transgenic mice, indicating the presence of VSMC-specific element(s) in this fragment.
Journal ArticleDOI
Tissue factor pathway inhibitor-2 gene methylation is associated with low expression in carotid atherosclerotic plaques.
Christophe Zawadzki,Nicolas Chatelain,Marianne Delestre,Sophie Susen,Bruno Quesnel,Francis Juthier,Emmanuelle Jeanpierre,Richard Azzaoui,Delphine Corseaux,Joke Breyne,Gérard Torpier,Bart Staels,Eric Van Belle,Brigitte Jude +13 more
TL;DR: Methylation of the TFPI-2 gene takes place in atherosclerotic plaques and is associated with decreased TFPi-2 expression, and the place of this process in Atherosclerosis progression remains to be investigated.
Journal ArticleDOI
Diagnostic Value of Stool Dna Testing for Multiple Markers Of Colorectal Cancer and Advanced Adenoma: A Meta-Analysis
Hua Yang,Bingqing Xia,Bo Jiang,Guozhen Wang,Yi-Peng Yang,Hao Chen,Bingsheng Li,Angao Xu,Yun-Bo Huang,Xin-Ying Wang +9 more
TL;DR: In this article, a meta-analysis was performed to evaluate the diagnostic value of sDNA testing for multiple markers of colorectal cancer (CRC) and advanced adenoma.
Journal ArticleDOI
Synthesis of universal unmethylated control DNA by nested whole genome amplification with ϕ29 DNA polymerase
TL;DR: Assessment of microsatellite markers demonstrated that even nested phi29 WGA achieves highly accurate and homogeneous amplification with very low amounts of genomic DNA as an initial template.
References
More filters
Journal ArticleDOI
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Journal ArticleDOI
CpG-rich islands and the function of DNA methylation
TL;DR: It is likely that most vertebrate genes are associated with ‘HTF islands’—DNA sequences in which CpG is abundant and non-methylated; however, highly tissue-specific genes, though, usually lack islands.
Journal ArticleDOI
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
Joe D. Lewis,Joe D. Lewis,Richard R. Meehan,Richard R. Meehan,William J. Henzel,Ingrid Maurer-Fogy,Peter Jeppesen,Franz Klein,Adrian Bird,Adrian Bird +9 more
TL;DR: This work reports the identification, purification, and cDNA cloning of a novel MeCP called MeCP2, which unlike MeCP1, the new protein is able to bind to DNA that contains a single methyl-CpG pair.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
Joan Boyes,Adrian Bird +1 more
TL;DR: Repression of transcription in vitro for four different promoters was shown to be an indirect effect and the mediator of repression had properties indistinguishable from those of a methyl-CpG binding protein (MeCP-1) that has been previously identified.