M
Matthias W. Beckmann
Researcher at University of Erlangen-Nuremberg
Publications - 913
Citations - 40161
Matthias W. Beckmann is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 83, co-authored 836 publications receiving 33443 citations. Previous affiliations of Matthias W. Beckmann include National Institutes of Health & University of Chicago.
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Journal ArticleDOI
Identification of Novel Genetic Markers of Breast Cancer Survival
Qi Guo,Marjanka K. Schmidt,Peter Kraft,Sander Canisius,Constance Chen,Sofia Khan,Jonathan Tyrer,Manjeet K. Bolla,Qin Wang,Joe Dennis,Kyriaki Michailidou,Michael Lush,Siddhartha Kar,Jonathan Beesley,Alison M. Dunning,Mitul Shah,Kamila Czene,Hatef Darabi,Mikael Eriksson,Diether Lambrechts,Diether Lambrechts,Caroline Weltens,Karin Leunen,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Jenny Chang-Claude,Anja Rudolph,Petra Seibold,Dieter Flesch-Janys,Carl Blomqvist,Kristiina Aittomäki,Rainer Fagerholm,Taru A. Muranen,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Irene L. Andrulis,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Annegien Broeks,Frans B. L. Hogervorst,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,John L. Hopper,Helen Tsimiklis,Carmel Apicella,Melissa C. Southey,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Graham G. Giles,Graham G. Giles,Roger L. Milne,Roger L. Milne,Catriona McLean,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Maartje J. Hooning,Antoinette Hollestelle,John W.M. Martens,Ans M.W. van den Ouweland,Federik Marme,Federik Marme,Andreas Schneeweiss,Andreas Schneeweiss,Rongxi Yang,Barbara Burwinkel,Barbara Burwinkel,Jonine D. Figueroa,Stephen J. Chanock,Stephen J. Chanock,Jolanta Lissowska,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Bernd Holleczek,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Jingmei Li,Judith S. Brand,Keith Humphreys,Peter Devilee,Rob A. E. M. Tollenaar,Caroline M. Seynaeve,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Paolo Mariani,Peter A. Fasching,Matthias W. Beckmann,Alexander Hein,Arif B. Ekici,Georgia Chenevix-Trench,Rosemary L. Balleine,Rosemary L. Balleine,Kelly-Anne Phillips,Kelly-Anne Phillips,Javier Benítez,M. Pilar Zamora,Jose Ignacio Arias Perez,Primitiva Menéndez,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,U Hamann,Maria Kabisch,Hans Ulrich Ulmer,Thomas Rüdiger,Sara Margolin,Vessela N. Kristensen,Vessela N. Kristensen,Silje Nord,Silje Nord,D. Gareth Evans,Jean Abraham,Jean Abraham,Helena M. Earl,Helena M. Earl,Louise Hiller,Janet A. Dunn,Sarah Bowden,Christine D. Berg,D. Campa,D. Campa,W. Ryan Diver,Susan M. Gapstur,Mia M. Gaudet,Susan E. Hankinson,Susan E. Hankinson,Robert N. Hoover,Anika Hüsing,Rudolf Kaaks,Mitchell J. Machiela,Walter C. Willett,Myrto Barrdahl,Federico Canzian,Suet-Feung Chin,Carlos Caldas,Carlos Caldas,David J. Hunter,Sara Lindström,Montserrat Garcia-Closas,Per Hall,Douglas F. Easton,Diana Eccles,Nazneen Rahman,Heli Nevanlinna,Paul D.P. Pharoah +163 more
TL;DR: The results of this large meta-analysis of studies in populations of European ancestry confirm that germline genotype can provide prognostic information in addition to standard tumor prognostic factors.
Journal ArticleDOI
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
Juliet D. French,Maya Ghoussaini,Stacey L. Edwards,Kerstin B. Meyer,Kyriaki Michailidou,Shahana Ahmed,Sofia Khan,Mel Maranian,Martin O'Reilly,Kristine M. Hillman,Joshua A. Betts,Thomas L. Carroll,Peter Bailey,Ed Dicks,Jonathan Beesley,Jonathan Tyrer,Ana-Teresa Maia,Andrew H. Beck,Nicholas W. Knoblauch,Constance Chen,Peter Kraft,Daniel R. Barnes,Anna González-Neira,M. Rosario Alonso,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Don M. Conroy,Joe Dennis,Manjeet K. Bolla,Qin Wang,John L. Hopper,Melissa C. Southey,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Peter A. Fasching,Peter A. Fasching,Christian R. Loehberg,Arif B. Ekici,Matthias W. Beckmann,Julian Peto,Isabel dos Santos Silva,Nichola Johnson,Zoe Aitken,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Roger L. Milne,M. Pilar Zamora,Jose Ignacio Arias Perez,Javier Benitez,Hoda Anton-Culver,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Alfons Meindl,Peter Lichtner,Rita K. Schmutzler,Christoph Engel,Hiltrud Brauch,Ute Hamann,Christina Justenhoven,Kirsimari Aaltonen,Päivi Heikkilä,Kristiina Aittomäki,Carl Blomqvist,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Annika Lindblom,Sara Margolin,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Diether Lambrechts,Stéphanie Peeters,Ann Smeets,Giuseppe Floris,Jenny Chang-Claude,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Domenico Sardella,Fergus J. Couch,Xianshu Wang,Vernon S. Pankratz,Adam M. Lee,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Jacques Simard,Mark S. Goldberg,Martine Dumont,Soo Hwang Teo,Cheng Har Yip,Char Hong Ng,Eranga N. Vithana,Vessela N. Kristensen,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Peter Devilee,Caroline M. Seynaeve,Montserrat Garcia-Closas,Jonine D. Figueroa,Stephen J. Chanock,Jolanta Lissowska,Kamila Czene,Daniel Klevebring,Nils Schoof,Maartje J. Hooning,John W.M. Martens,J. Margriet Collée,Madeleine M.A. Tilanus-Linthorst,Per Hall,Jingmei Li,Jianjun Liu,Keith Humphreys,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Angela Cox,Sabapathy P. Balasubramanian,William Blot,Lisa B. Signorello,Qiuyin Cai,Paul D.P. Pharoah,Catherine S. Healey,Mitul Shah,Karen A. Pooley,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Mikael Hartman,Hui Miao,J. H. Sng,Xueling Sim,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Suleeporn Sangrajrang,Valerie Gaborieau,James McKay,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Andrew K. Godwin,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shou Tung Chen,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Bruce A.J. Ponder,Heli Nevanlinna,Melissa A. Brown,Georgia Chenevix-Trench,Douglas F. Easton,Alison M. Dunning +214 more
TL;DR: Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13, and Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1.
Journal ArticleDOI
Hereditary breast and ovarian cancer: review and future perspectives
TL;DR: Prophylactic mastectomy and bilateral ovariectomy are the only options that lead to a demonstrable reduction in risk, but they do, of course, affect the patient’s physical integrity.
Journal ArticleDOI
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Haoyu Zhang,Haoyu Zhang,Thomas U. Ahearn,Julie Lecarpentier,Daniel R. Barnes,Jonathan Beesley,Guanghao Qi,Xia Jiang,Tracy A. O'Mara,Ni Zhao,Manjeet K. Bolla,Alison M. Dunning,Joe Dennis,Qin Wang,Zumuruda Abu Ful,Kristiina Aittomäki,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Jacopo Azzollini,Daniel Barrowdale,Heiko Becher,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Katarzyna Białkowska,Ana Blanco,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Bernardo Bonanni,Davide Bondavalli,Åke Borg,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Ignacio Briceño,Annegien Broeks,Sara Y Brucker,Thomas Brüning,Barbara Burwinkel,Saundra S. Buys,Helen Byers,Trinidad Caldés,Maria A. Caligo,Mariarosaria Calvello,Daniele Campa,Jose E. Castelao,Jenny Chang-Claude,Stephen J. Chanock,Melissa Christiaens,Hans Christiansen,Wendy K. Chung,Kathleen Claes,Christine L. Clarke,Sten Cornelissen,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Mary B. Daly,Peter Devilee,Orland Diez,Susan M. Domchek,Thilo Dörk,Miriam Dwek,Diana Eccles,Arif B. Ekici,D. Gareth Evans,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Lenka Foretova,Florentia Fostira,Eitan Friedman,Debra Frost,Manuela Gago-Dominguez,Susan M. Gapstur,Judy Garber,José A. García-Sáenz,Mia M. Gaudet,Simon A. Gayther,Graham G. Giles,Graham G. Giles,Graham G. Giles,Andrew K. Godwin,Mark S. Goldberg,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Mark H. Greene,Jacek Gronwald,Pascal Guénel,Lothar Häberle,Eric Hahnen,Christopher A. Haiman,Christopher R. Hake,Per Hall,Ute Hamann,Elaine F. Harkness,Elaine F. Harkness,Bernadette A M Heemskerk-Gerritsen,Peter Hillemanns,Frans B. L. Hogervorst,Bernd Holleczek,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Anthony Howell,Hanna Huebner,Peter J. Hulick,Evgeny N. Imyanitov,Claudine Isaacs,Louise Izatt,Agnes Jager,Milena Jakimovska,Anna Jakubowska,Anna Jakubowska,Paul A. James,Ramunas Janavicius,Wolfgang Janni,Esther M. John,Michael Jones,Audrey Y. Jung,Rudolf Kaaks,Pooja Middha Kapoor,Beth Y. Karlan,Renske Keeman,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Cari M. Kitahara,Yon-Dschun Ko,Irene Konstantopoulou,Linetta B. Koppert,Stella Koutros,Vessela N. Kristensen,Vessela N. Kristensen,Anne-Vibeke Lænkholm,Diether Lambrechts,Susanna C. Larsson,Susanna C. Larsson,Pierre Laurent-Puig,Conxi Lázaro,Emilija Lazarova,Flavio Lejbkowicz,Goska Leslie,Fabienne Lesueur,Annika Lindblom,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Jennifer T. Loud,Jan Lubinski,Alicja Lukomska,Robert J. MacInnis,Robert J. MacInnis,Arto Mannermaa,Mehdi Manoochehri,Siranoush Manoukian,Sara Margolin,Maria Elena Martinez,Laura Matricardi,Lesley McGuffog,Catriona McLean,Noura Mebirouk,Alfons Meindl,Usha Menon,Austin Miller,Elvira Mingazheva,Marco Montagna,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Taru A. Muranen,Katherine L. Nathanson,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,William G. Newman,Finn Cilius Nielsen,Liene Nikitina-Zake,Jesse Nodora,Kenneth Offit,Edith Olah,Olufunmilayo I. Olopade,Olufunmilayo I. Olopade,Håkan Olsson,Håkan Olsson,Nick Orr,Laura Papi,János Papp,Tjoung-Won Park-Simon,Michael T. Parsons,Bernard Peissel,Ana Peixoto,Beth N. Peshkin,Paolo Peterlongo,J. Peto,J. Peto,Kelly-Anne Phillips,Kelly-Anne Phillips,Marion Piedmonte,Dijana Plaseska-Karanfilska,Karolina Prajzendanc,Ross L. Prentice,Darya Prokofyeva,Brigitte Rack,Paolo Radice,Susan J. Ramus,Susan J. Ramus,Johanna Rantala,Muhammad Usman Rashid,Gad Rennert,Hedy S. Rennert,Harvey A. Risch,Atocha Romero,Matti A. Rookus,Matthias Rübner,Thomas Rüdiger,Emmanouil Saloustros,Sarah Sampson,Dale P. Sandler,Elinor J. Sawyer,Maren T. Scheuner,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Ben Schöttker,Peter Schürmann,Leigha Senter,Priyanka Sharma,Mark E. Sherman,Xiao-Ou Shu,Christian F. Singer,Snezhana Smichkoska,Penny Soucy,Melissa C. Southey,John J. Spinelli,Jennifer Stone,Jennifer Stone,Dominique Stoppa-Lyonnet,Anthony J. Swerdlow,Csilla Szabo,Rulla M. Tamimi,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Manuel R. Teixeira,M. B. Terry,Mads Thomassen,Darcy L. Thull,Marc Tischkowitz,Marc Tischkowitz,Amanda E. Toland,Rob A. E. M. Tollenaar,Ian Tomlinson,Ian Tomlinson,Diana Torres,Melissa A. Troester,Thérèse Truong,Nadine Tung,Michael Untch,Celine M. Vachon,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Elke M van Veen,Elizabeth J. van Rensburg,Ana Vega,Barbara Wappenschmidt,Clarice R. Weinberg,Jeffrey N. Weitzel,Hans Wildiers,Robert Winqvist,Alicja Wolk,Alicja Wolk,Alicja Wolk,Xiaohong R. Yang,Drakoulis Yannoukakos,Wei Zheng,Kristin K. Zorn,Roger L. Milne,Roger L. Milne,Roger L. Milne,Peter Kraft,Jacques Simard,Paul D.P. Pharoah,Kyriaki Michailidou,Kyriaki Michailidou,Antonis C. Antoniou,Marjanka K. Schmidt,Georgia Chenevix-Trench,Douglas F. Easton,Nilanjan Chatterjee,Montserrat Garcia-Closas +302 more
TL;DR: A genome-wide association study including 133,384 breast cancer cases and 113,789 controls plus 18,908 BRCA1 mutation carriers of European ancestry provides an improved understanding of genetic predisposition to breast cancer subtypes and will inform the development of subtype-specific polygenic risk scores.
Journal ArticleDOI
DNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
Andrew E. Teschendorff,Yang Gao,Allison Jones,Matthias Ruebner,Matthias W. Beckmann,David L. Wachter,Peter A. Fasching,Martin Widschwendter +7 more
TL;DR: The DNA methylome of 569 breast tissue samples is analysed and it is demonstrated that normal tissue adjacent to breast cancer is characterized by tens to thousands of epigenetic alterations, and their genomic distribution is non-random.