M
Michael Egholm
Researcher at Hoffmann-La Roche
Publications - 125
Citations - 56141
Michael Egholm is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Nucleic acid & Nucleic acid analogue. The author has an hindex of 72, co-authored 125 publications receiving 52712 citations. Previous affiliations of Michael Egholm include University of Cambridge & Nielsen Holdings N.V..
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Journal ArticleDOI
Genome sequencing in microfabricated high-density picolitre reactors
Marcel Margulies,Michael Egholm,William E. Altman,Said Attiya,Joel S. Bader,Lisa A. Bemben,Jan Berka,Michael S. Braverman,Yi-Ju Chen,Zhoutao Chen,Scott Dewell,Lei Du,J. M. Fierro,Xavier V. Gomes,Brian C. Godwin,Wen He,Scott Edward Helgesen,Chun Heen Ho,Gerard P. Irzyk,Szilveszter C. Jando,Maria L. I. Alenquer,Thomas P. Jarvie,Kshama B. Jirage,Jong-Bum Kim,James R. Knight,Janna R. Lanza,John H. Leamon,Steven Lefkowitz,Ming Lei,Jing Li,Kenton Lohman,Hong Lu,Vinod Makhijani,Keith Mcdade,Michael P. McKenna,Eugene W. Myers,Elizabeth Nickerson,John Nobile,Ramona Plant,Bernard P. Puc,Michael T. Ronan,George T. Roth,Gary J. Sarkis,Jan Fredrik Simons,John Simpson,Maithreyan Srinivasan,Karrie R. Tartaro,Alexander Tomasz,Kari A. Vogt,Greg A. Volkmer,Shally H. Wang,Yong Wang,Michael P. Weiner,Pengguang Yu,Richard F. Begley,Jonathan M. Rothberg +55 more
TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
Journal ArticleDOI
A core gut microbiome in obese and lean twins
Peter J. Turnbaugh,Micah Hamady,Tanya Yatsunenko,Brandi L. Cantarel,Alexis E. Duncan,Ruth E. Ley,Mitchell L. Sogin,William J. Jones,Bruce A. Roe,Jason P. Affourtit,Michael Egholm,Bernard Henrissat,Andrew C. Heath,Rob Knight,Jeffrey I. Gordon +14 more
TL;DR: The faecal microbial communities of adult female monozygotic and dizygotic twin pairs concordant for leanness or obesity, and their mothers are characterized to address how host genotype, environmental exposure and host adiposity influence the gut microbiome.
Journal ArticleDOI
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
TL;DR: The results show that the backbone of DNA can be replaced by a polyamide, with the resulting oligomer retaining base-specific hybridization.
Journal ArticleDOI
A Draft Sequence of the Neandertal Genome
Richard E. Green,Johannes Krause,Adrian W. Briggs,Tomislav Maricic,Udo Stenzel,Martin Kircher,Nick Patterson,Heng Li,Weiwei Zhai,Markus Hsi-Yang Fritz,Nancy F. Hansen,Eric Durand,Anna-Sapfo Malaspinas,Jeffrey D. Jensen,Tomas Marques-Bonet,Tomas Marques-Bonet,Can Alkan,Kay Prüfer,Matthias Meyer,Hernán A. Burbano,Jeffrey M. Good,Jeffrey M. Good,Rigo Schultz,Ayinuer Aximu-Petri,Anne Butthof,Barbara Höber,Barbara Höffner,Madien Siegemund,Antje Weihmann,Chad Nusbaum,Eric S. Lander,Carsten Russ,Nathaniel Novod,Jason P. Affourtit,Michael Egholm,Christine Verna,Pavao Rudan,Dejana Brajković,Željko Kućan,Ivan Gušić,Vladimir B. Doronichev,Liubov V. Golovanova,Carles Lalueza-Fox,Marco de la Rasilla,Javier Fortea,Antonio Rosas,Ralf Schmitz,Philip L. F. Johnson,Evan E. Eichler,Daniel Falush,Ewan Birney,James C. Mullikin,Montgomery Slatkin,Rasmus Nielsen,Janet Kelso,Michael Lachmann,David Reich,David Reich,Svante Pääbo +58 more
TL;DR: The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Journal ArticleDOI
The tomato genome sequence provides insights into fleshy fruit evolution
Shusei Sato,Satoshi Tabata,Hideki Hirakawa,Erika Asamizu,Kenta Shirasawa,Sachiko Isobe,Takakazu Kaneko,Yasukazu Nakamura,Daisuke Shibata,Koh Aoki,Michael Egholm,James R. Knight,Robert Bogden,Changbao Li,Yang Shuang,Xun Xu,Shengkai Pan,Shifeng Cheng,Xin Liu,Yuanyuan Ren,Jun Wang,Alessandro Albiero,Francesca Dal Pero,Sara Todesco,Joyce Van Eck,Robert M. Buels,Aureliano Bombarely,Joseph Gosselin,Minyun Huang,Jonathan A. Leto,Naama Menda,Susan R. Strickler,Linyong Mao,Shan Gao,Isaak Y. Tecle,Thomas L. York,Yi Zheng,Julia Vrebalov,Je Min Lee,Silin Zhong,Lukas A. Mueller,Willem J. Stiekema,Paolo Ribeca,Tyler Alioto,Wencai Yang,Sanwen Huang,Yongchen Du,Zhonghua Zhang,Jianchang Gao,Yanmei Guo,Xiaoxuan Wang,Ying Li,Jun He,Chuanyou Li,Zhukuan Cheng,Jianru Zuo,Jianfeng Ren,Jiuhai Zhao,Liuhua Yan,Hongling Jiang,Bao Wang,Hongshuang Li,Zhenjun Li,Fuyou Fu,Bingtang Chen,Bin Han,Qi Feng,Danlin Fan,Ying Wang,Hong-Qing Ling,Yongbiao Xue,Doreen Ware,W. Richard McCombie,Zachary B. Lippman,Jer Ming Chia,Ke Jiang,Shiran Pasternak,Laura Gelley,Melissa Kramer,Lorinda K. Anderson,Song Bin Chang,Suzanne M. Royer,Lindsay A. Shearer,Stephen M. Stack,Jocelyn K. C. Rose,Yimin Xu,Nancy T. Eannetta,Antonio J. Matas,Ryan P. McQuinn,Steven D. Tanksley,Francisco Camara,Roderic Guigó,Stephane Rombauts,Jeffrey A. Fawcett,Yves Van de Peer,Dani Zamir,Chunbo Liang,Manuel Spannagl,Heidrun Gundlach,Rémy Bruggmann,Klaus F. X. Mayer,Zhiqi Jia,Junhong Zhang,Zhibiao Ye,Gerard J. Bishop,Sarah Butcher,Rosa Lopez-Cobollo,Daniel W. A. Buchan,Ioannis Filippis,James Abbott,Manju Singh,Alok Singh,Jitendra Kumar Pal,Awadhesh Pandit,Pradeep Kumar Singh,Ajay Kumar Mahato,Vivek Dogra,Kishor Gaikwad,Tilak Raj Sharma,Trilochan Mohapatra,Nagendra K. Singh,Mathilde Causse,Christophe Rothan,Céline Noirot,Arnaud Bellec,Christophe Klopp,Corinne Delalande,Hélène Bergès,Jérôme Mariette,Pierre Frasse,Sonia Vautrin,Toulouse Mohamed Zouine,Alain Latché,Christine Rousseau,Farid Regad,Jean-Claude Pech,Murielle Philippot,Mondher Bouzayen,Pierre Pericard,Sonia Osorio,Asuncion Fernandez Del Carmen,Antonio J. Monforte,Antonio Granell,Rafael Fernández-Muñoz,Mariana Conte,Gabriel Lichtenstein,Fernando Carrari,Gianluca De Bellis,Fabio Fuligni,Clelia Peano,Silvana Grandillo,Pasquale Termolino,Marco Pietrella,Elio Fantini,Giulia Falcone,Alessia Fiore,Giovanni Giuliano,Loredana Lopez,Paolo Facella,Gaetano Perrotta,Loretta Daddiego,Glenn J. Bryan,Biology Modesto Orozco,Xavier Pastor,David Torrents,Marco G.M. Van Schriek,Richard Feron,Jan van Oeveren,Peter De Heer,Lorena Da Ponte,Saskia Jacobs-Oomen,Mike Cariaso,Marcel Prins,Michael Josephus Theresia Van Eijk,Antoine Janssen,J. J. Van Haaren,Sung HwanJo,Jungeun Kim,Suk-Yoon Kwon,Sangmi Kim,Dal-Hoe Koo,Sanghyeob Lee,Christopher Clouser,Alain Rico,Asis Hallab,Christiane Gebhardt,Kathrin Klee,Anika Jöcker,Jens Warfsmann,Ulrike Göbel,Shingo Kawamura,Kentaro Yano,Jamie D. Sherman,Hiroyuki Fukuoka,Satomi Negoro,Sarita Bhutty,Parul Chowdhury,Debasis Chattopadhyay,Erwin Datema,Sandra Smit,Elio Schijlen,José van de Belt,Jan C. van Haarst,Sander Peters,Marjo J. van Staveren,Marleen H.C. Henkens,Paul Mooyman,Thamara Hesselink,Roeland C. H. J. van Ham,Guoyong Jiang,Marcus Droege,Doil Choi,Byung Cheol Kang,Byung-Dong Kim,Minkyu Park,Seungill Kim,Seon-In Yeom,Yong-Hwan Lee,Yang Do Choi,Guangcun Li,Jianwei Gao,Yongsheng Liu,Shengxiong Huang,Victoria Fernandez-Pedrosa,Carmen Collado,Sheila Zuñ Iga,Guoping Wang,Rebecca Cade,Robert A. Dietrich,Jane Rogers,Sandra Knapp,Zhangjun Fei,Zhangjun Fei,Ruth White,Ruth White,Theodore W. Thannhauser,Theodore W. Thannhauser,James J. Giovannoni,James J. Giovannoni,Miguel A. Botella,Louise Gilbert,Fabra Ramon Gonzalez,Jose Luis Goicoechea,Yeisoo Yu,David Kudrna,Kristi Collura,Marina Wissotski,Rod A. Wing,Blake C. Meyers,Aishwarya Bala Gurazada,Pamela J. Green,Saloni Mathur,Shailendra Vyas,Amolkumar U. Solanke,Rajesh Kumar,Vikrant Gupta,Arun Sharma,Paramjit Khurana,Jitendra P. Khurana,Akhilesh K. Tyagi,Tamas Dalmay,Irina Mohorianu,Brandon Walts,Srikar Chamala,W. Brad Barbazuk,Jingping Li,Hui Guo,Tae-Ho Lee,Yupeng Wang,Dong Zhang,Andrew H. Paterson,Xiyin Wang,Xiyin Wang,Haibao Tang,Haibao Tang,Amalia Barone,Maria Luisa Chiusano,Maria Raffaella Ercolano,Nunzio D’Agostino,Miriam Di Filippo,Alessandra Traini,Walter Sanseverino,Luigi Frusciante,Graham B. Seymour,Mounir Elharam,Ying Fu,Axin Hua,Steven Kenton,Jennifer Lewis,Shaoping Lin,Fares Z. Najar,Hongshing Lai,Baifang Qin,Ruihua Shi,Chunmei Qu,Douglas White,James R. White,Yanbo Xing,Keqin Yang,Jing Yi,Ziyun Yao,Liping Zhou,Bruce A. Roe,Alessandro Vezzi,Michela D'Angelo,Rosanna Zimbello,Riccardo Schiavon,Elisa Caniato,Chiara Rigobello,Davide Campagna,Nicola Vitulo,Giorgio Valle,David R. Nelson,Emanuele De Paoli,Dóra Szinay,Hans H. De Jong,Yuling Bai,Richard G. F. Visser,Reném Klein Lankhorst,Helen Beasley,Karen McLaren,Christine Nicholson,Claire Riddle,Giulio Gianese +323 more
TL;DR: A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome.