Annamalai University

About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.

Multiple Performance Optimization of Machining Parameters on the Machining of GFRP Composites Using Carbide (K10) Tool

Abstract: The present investigation focuses on the multiple performance machining characteristics of GFRP composites produced through filament winding. Grey relational analysis was used for the optimization of the machining parameters on machining GFRP composites using carbide (K10) tool. According to the Taguchi quality concept, a L27, 3-level orthogonal array was chosen for the experiments. The machining parameters namely work piece fiber orientation, cutting speed, feed rate, depth of cut and machining time have been optimized based on the multiple performance characteristics including material removal rate, tool wear, surface roughness and specific cutting pressure. Experimental results have shown that machining performance in the composite machining process can be improved effectively by using this approach.

Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.

Abstract: Curcumin is the most active component of turmeric. It is believed that curcumin is a potent antioxidant and anti-inflammatory agent. Tetrahydrocurcumin is one of the major metabolites of curcumin that exhibits many of the same physiologic and pharmacological activities as curcumin and in some systems may exert greater antioxidant activity than curcumin. Oral administration of tetrahydrocurcumin at 80 mg/kg body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, the diabetic rats had decreased levels of plasma total protein, albumin, globulin and albumin/globulin ratio as compared to control rats. After treatment with tetrahydrocurcumin and curcumin total protein, albumin, globulin and albumin/globulin ratio were brought back to near normal. The activities of hepatic and renal markers were significantly elevated in diabetic rats as compared to control rats, and treatment with tetrahydrocurcumin and curcumin has reversed these parameters to near normal levels. In diabetic rats, the decreased levels of urea, uric acid and creatinine with increased levels of albumin and urine volume was observed, and treatment with tetrahydrocurcumin and curcumin reversed these parameters to near normal. Tetrahydrocurcumin appeared to have a better protective effect when compared to curcumin.

Stimulation of glucose utilization and inhibition of protein glycation and AGE products by taurine.

Abstract: Aim: Pathological effects of the process of non-enzymatic glycation of proteins are reflected in chronic complications of diabetes mellitus We investigated the antiglycating effect of taurine in high fructose fed rats in vivo and the inhibiting potency of taurine in the process of in vitro glycation Additionally, we investigated whether taurine enhances glucose utilization in the rat diaphragm Methods: Rats fed a high fructose diet (60% total calories) were provided 2% taurine solution for 30 days The effects of taurine on plasma glucose, fructosamine, protein glycation and glycosylated haemoglobin in high fructose rats were determined For in vitro glycation a mixture of 25 mm glucose and 25 mm fructose was used as glycating agent, bovine serum albumin as the model protein and taurine as the inhibitor Incubations were carried out in a constant temperature bath at 37 °C for 3–30 days Amadori products and advanced glycation end products (AGEs) formed were measured In vitro utilization of glucose was carried out in the rat diaphragm in the presence and absence of insulin in which taurine was used as an additive Results: The contents of glucose, glycated protein, glycosylated haemoglobin and fructosamine were significantly lowered by taurine treatment to high fructose rats Taurine prevented in vitro glycation and the accumulation of AGEs Furthermore, taurine enhanced glucose utilization in the rat diaphragm This effect was additive to that of insulin and did not interfere with the action of insulin Conclusions: These results underline the potential use of taurine as a therapeutic supplement for the prevention of diabetic pathology