Institution
Annamalai University
Education•Chidambaram, Tamil Nadu, India•
About: Annamalai University is a education organization based out in Chidambaram, Tamil Nadu, India. It is known for research contribution in the topics: Lipid peroxidation & Antioxidant. The organization has 8098 authors who have published 10758 publications receiving 203872 citations.
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that silibinin has a potential protective effect over arsenic-induced hepatotoxicity in rat, supported by reduction of DNA damage in hepatocytes and histopathological observations of the liver.
Abstract: Arsenic (As) compounds are reported as environmental toxicants and human carcinogens. Exposure to arsenic imposes a big health issue worldwide. Silibinin (SB) is a major flavonolignan compound of silimarin and is found in milk thistle of Silybum marianum. It has been reported that silibinin has antioxidant efficacy as metal chelators due to the orientation of its functional groups. However, it has not yet been explored in experimental animals. In view of this fact, the purpose of this study was to delineate the ameliorative role of silibinin against arsenic-induced hepatotoxicity in rats. Rats were orally treated with arsenic alone (5 mg/kg body weight (bw)/day) plus silibinin (75 mg/kg bw/day) for 4weeks. Hepatotoxicity was evaluated by the increased activities of serum hepatospecific enzymes namely aspartate transaminase, alanine transaminase, alkaline phosphatase, gamma glutamyl transferase, lactate dehydrogenase and total bilirubin along with increased elevation of lipid peroxidative markers, thiobarb...
69 citations
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TL;DR: The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis.
69 citations
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TL;DR: The results of the study reveal that sesbania could afford a significant protective effect against erythromycin estolate-induced hepatotoxicity and was compared with that of silymarin, a reference hepatoprotective drug.
Abstract: Sesbania grandiflora, commonly known as 'sesbania', is widely used in Indian folk medicine for the treatment of liver disorders. Oral administration of an ethanolic extract of S. grandiflora leaves (200 mg/kg/day) for 15 days produced significant hepatoprotection against erythromycin estolate (800 mg/kg/day)-induced hepatotoxicity in rats. The increased level of serum enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase), bilirubin, cholesterol, triglycerides, phospholipids, free fatty acids, plasma thiobarbituric acid reactive substances and hydroperoxides observed in rats treated with erythromycin estolate were significantly decreased in rats treated concomitantly with sesbania extract and erythromycin estolate. The sesbania extract also restored the depressed levels of antioxidants to near normal. The results of the study reveal that sesbania could afford a significant protective effect against erythromycin estolate-induced hepatotoxicity. The effect of sesbania was compared with that of silymarin, a reference hepatoprotective drug.
69 citations
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TL;DR: All SL supplemented diets showed a marked increase in apparent crude lipid digestibility (ACLD) than the diets without SL, and there was no significant difference in survival of shrimp among the dietary treatments.
69 citations
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TL;DR: Overall, this research shed light on the mosquitocidal potential of C. carandas, a potential bio-resource for rapid, cheap and effective synthesis of poly-disperse and stable silver nanocrystals.
Abstract: Mosquito-borne diseases represent a major human and animal health problem in all tropical and subtropical countries worldwide. In this study, we investigated the one-pot synthesis of silver nanoparticles (AgNPs) using a cheap leaf extract of Carissa carandas (Apocynaceae). Bio-reduced AgNPs were characterized by UV–visible spectrophotometry, Fourier transform infrared spectroscopy, X-ray diffraction analysis, atomic force microscopy, scanning electron microscopy and transmission electron microscopy. The acute toxicity of C. carandas extract and green-synthesized AgNPs was evaluated on eggs and larvae of Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. AgNPs showed high toxicity against A. stephensi, A. aegypti, and C. quinquefasciatus larvae with LC50 values of 14.33, 15.69 and 16.95 μg/mL, respectively. A single treatment with AgNPs tested at 60 μg/mL led to no egg hatchability. The egg rafts of C. quinquefasciatus were more resistant to the toxic action of AgNPs if compared to A. aegypti and A. stephensi. C. carandas-fabricated AgNPs were found safer to non-target organisms Anisops bouvieri, Diplonychus indicus and Gambusia affinis, with LC50 ranging from 1097.87 to 17249.89 µg/ml. Overall, this research shed light on the mosquitocidal potential of C. carandas, a potential bio-resource for rapid, cheap and effective synthesis of poly-disperse and stable silver nanocrystals.
69 citations
Authors
Showing all 8164 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dinesh Mohan | 79 | 283 | 35775 |
Sampath Parthasarathy | 77 | 268 | 34280 |
Mandyam V. Srinivasan | 68 | 344 | 15572 |
Leelavinothan Pari | 58 | 160 | 8374 |
Venugopal P. Menon | 54 | 195 | 10111 |
Kadarkarai Murugan | 54 | 286 | 9280 |
V. Balasubramanian | 54 | 457 | 10951 |
Marimuthu Govindarajan | 52 | 212 | 6738 |
Annamalai Subramanian | 49 | 95 | 6021 |
Meenakshisundaram Swaminathan | 48 | 239 | 8698 |
Siddavaram Nagini | 47 | 185 | 7371 |
Mohan K. Balasubramanian | 47 | 130 | 6238 |
Subash C. B. Gopinath | 45 | 455 | 7855 |
Sunil Sazawal | 44 | 111 | 9774 |
Al. Ramanathan | 43 | 235 | 6132 |