Institution
Moscow State University
Education•Moscow, Russia•
About: Moscow State University is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Catalysis & Laser. The organization has 66747 authors who have published 123358 publications receiving 1753995 citations. The organization is also known as: MSU & Lomonosov Moscow State University.
Topics: Catalysis, Laser, Population, Magnetic field, Crystal structure
Papers published on a yearly basis
Papers
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TL;DR: The study identifies an RNA virus ExoN activity that is involved in the synthesis of multiple RNAs from the exceptionally large genomic RNA templates of CoVs.
Abstract: Replication of the giant RNA genome of severe acute respiratory syndrome (SARS) coronavirus (CoV) and synthesis of as many as eight subgenomic (sg) mRNAs are mediated by a viral replicase-transcriptase of outstanding complexity that includes an essential endoribonuclease activity. Here, we show that the CoV replicative machinery, unlike that of other RNA viruses, also uses an exoribonuclease (ExoN) activity, which is associated with nonstructural protein (nsp) 14. Bacterially expressed forms of SARS-CoV nsp14 were shown to act on both ssRNAs and dsRNAs in a 3′→5′ direction. The activity depended on residues that are conserved in the DEDD exonuclease superfamily. The protein did not hydrolyze DNA or ribose-2′-O-methylated RNA substrates and required divalent metal ions for activity. A range of 5′-labeled ssRNA substrates were processed to final products of ≈8–12 nucleotides. When part of dsRNA or in the presence of nonlabeled dsRNA, the 5′-labeled RNA substrates were processed to significantly smaller products, indicating that binding to dsRNA in cis or trans modulates the exonucleolytic activity of nsp14. Characterization of human CoV 229E ExoN active-site mutants revealed severe defects in viral RNA synthesis, and no viable virus could be recovered. Besides strongly reduced genome replication, specific defects in sg RNA synthesis, such as aberrant sizes of specific sg RNAs and changes in the molar ratios between individual sg RNA species, were observed. Taken together, the study identifies an RNA virus ExoN activity that is involved in the synthesis of multiple RNAs from the exceptionally large genomic RNA templates of CoVs.
545 citations
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TL;DR: In this paper, the amplitude of a response and time to return to the current state before application of stress could serve as measures of soil health, and the occurrence of epiphytotics forms an indication of an ecosystem in distress.
544 citations
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TL;DR: This work experimentally demonstrate two examples of high-efficiency polarization-sensitive dielectric metasurfaces with 2π phase control in transmission mode with high transmission efficiency at telecommunication wavelengths.
Abstract: Metasurfaces are two-dimensional structures enabling complete control on light amplitude, phase, and polarization. Unlike plasmonic metasurfaces, silicon structures facilitate high transmission, low losses, and compatibility with existing semiconductor technologies. We experimentally demonstrate two examples of high-efficiency polarization-sensitive dielectric metasurfaces with 2π phase control in transmission mode (45% transmission efficiency for the vortex converter and 36% transmission efficiency for the beam steering device) at telecommunication wavelengths. Silicon metasurfaces are poised to enable a versatile platform for the realization of all-optical circuitry on a chip.
543 citations
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TL;DR: This work implements a new physical mechanism for suppressing radiative losses of individual nanoscale resonators to engineer special modes with high quality factors: optical bound states in the continuum (BICs), and demonstrates that an individual subwavelength dielectric resonator hosting a BIC mode can boost nonlinear effects increasing second-harmonic generation efficiency.
Abstract: Subwavelength optical resonators made of high-index dielectric materials provide efficient ways to manipulate light at the nanoscale through mode interferences and enhancement of both electric and magnetic fields. Such Mie-resonant dielectric structures have low absorption, and their functionalities are limited predominantly by radiative losses. We implement a new physical mechanism for suppressing radiative losses of individual nanoscale resonators to engineer special modes with high quality factors: optical bound states in the continuum (BICs). We demonstrate that an individual subwavelength dielectric resonator hosting a BIC mode can boost nonlinear effects increasing second-harmonic generation efficiency. Our work suggests a route to use subwavelength high-index dielectric resonators for a strong enhancement of light-matter interactions with applications to nonlinear optics, nanoscale lasers, quantum photonics, and sensors.
543 citations
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TL;DR: Recent advances of smart nanocarriers composed of organic and inorganic materials offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine are highlighted.
Abstract: The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.
542 citations
Authors
Showing all 68238 results
Name | H-index | Papers | Citations |
---|---|---|---|
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
A. Gomes | 150 | 1862 | 113951 |
Robert J. Sternberg | 149 | 1066 | 89193 |
James M. Tour | 143 | 859 | 91364 |
Alexander Belyaev | 142 | 1895 | 100796 |
Rainer Wallny | 141 | 1661 | 105387 |
I. V. Gorelov | 139 | 1916 | 103133 |
António Amorim | 136 | 1477 | 96519 |
Halina Abramowicz | 134 | 1192 | 89294 |
Grigory Safronov | 133 | 1358 | 94610 |
Elizaveta Shabalina | 133 | 1421 | 92273 |
Alexander Zhokin | 132 | 1323 | 86842 |
Eric Conte | 132 | 1206 | 84593 |
Igor V. Moskalenko | 132 | 542 | 58182 |
M. Davier | 132 | 1449 | 107642 |