Nanjing Tech University

About: Nanjing Tech University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Membrane. The organization has 21827 authors who have published 21794 publications receiving 364050 citations. The organization is also known as: Nangongda & Nánjīng Gōngyè Dàxúe.

Nanocarriers and Their Loading Strategies.

Abstract: Nanocarriers are of paramount significance for drug delivery and nanomedicine technology. Given the imperfect systems and nonideal therapeutic effects, there are works to be done in synthesis as much as in biological studies, if not more so. Building the foundation of synthesis would offer more tools and deeper insights for exploring the biological systems with extreme complexity. This review aims at a broad-scope summary and classification of nanocarriers for drug delivery, with focus on the synthetic strategy and structural implications. The nanocarriers are divided into four categories according to the loading principle: molecular-level loading, surface loading, matrix loading, and cavity loading systems. Making comparisons across diverse nanocarrier systems would make it easier to see the fundamental characteristics, from where the weakness can be addressed and the strengths combined. The systematic comparisons may also inspire new ideas and methods.

Reusable and efficient polystyrene-supported acidic ionic liquid catalyst for esterifications

Abstract: Polystyrene (PS)-supported 1-(propyl-3-sulfonate) imidazolium hydrosulfate acidic ionic liquid (PS-CH 2 -[SO 3 H-pIM][HSO 4 ]) catalyst was prepared by supporting the ionic liquid onto highly cross-linked chloromethylated polystyrene (PS-CH 2 Cl). FT-IR, SEM and TG-DSC were employed to characterize the structure and property of the catalyst. Results suggested that acidic ionic liquid was supported onto the surface of PS-CH 2 Cl by covalent bond. The original rough surface of PS-CH 2 Cl was covered with acidic ionic liquid, forming a compact and thin surface layer, and its size had no obvious change. Moreover, the PS-CH 2 -[SO 3 H-pIM][HSO 4 ] catalyst showed a better thermal stability than that of PS-CH 2 Cl support. It also exhibited high catalytic activity for a series of esterifications. After the catalyst was reused for 13 times in the synthesis of n-butyl acetate, the yield only decreased 7.3%. A reaction mechanism of esterification over this new catalyst was proposed as well.

A novel bienzyme glucose biosensor based on three-layer Au–Fe3O4@SiO2 magnetic nanocomposite

Abstract: The magnetic core–shell Au–Fe3O4@SiO2 nanocomposite was prepared by layer-by-layer assembly technique and was used to fabricate a novel bienzyme glucose biosensor. Glucose oxidase (GOD) and horseradish peroxidase (HRP) were simply mixed with Au–Fe3O4@SiO2 nanocomposite and cross-linked on the ITO magnetism-electrode with nafion (Nf) and glutaraldehyde (GA). The modified electrode was designated as Nf–GOD–HRP/Au–Fe3O4@SiO2/ITO. The effects of some experimental variables such as the pH of supporting electrolyte, enzyme loading, the concentration of the mediator methylene blue (MB) and the applied potential were investigated. The electrochemical behavior of the biosensor was studied using electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and chronoamperometry. Under the optimized conditions, the biosensor showed a wide dynamic range for the detection of glucose with linear ranges of 0.05–1.0 mM and 1.0–8.0 mM, and the detection limit was estimated as 0.01 mM at a signal-to-noise ratio of 3. The biosensor exhibited a rapid response, good stability and anti-interference ability. Furthermore, the biosensor was successfully applied to detect glucose in human serum samples, showing acceptable accuracy with the clinical method.