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Institution

University of Konstanz

EducationKonstanz, Baden-Württemberg, Germany
About: University of Konstanz is a education organization based out in Konstanz, Baden-Württemberg, Germany. It is known for research contribution in the topics: Population & Membrane. The organization has 12115 authors who have published 27401 publications receiving 951162 citations. The organization is also known as: University of Constance & Universität Konstanz.
Topics: Population, Membrane, Politics, Laser, Gene


Papers
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Journal ArticleDOI
TL;DR: The results suggest that the Pe, rather than the Ne/ERN, is closely related to error detection, and specifically reflects the accumulated evidence that an error has been committed.
Abstract: The ability to detect and compensate for errors is crucial in producing effective, goal-directed behavior Human error processing is reflected in two event-related brain potential components, the error-related negativity (Ne/ERN) and error positivity (Pe), but the functional significance of both components remains unclear Our approach was to consider error detection as a decision process involving an evaluation of available evidence that an error has occurred against an internal criterion This framework distinguishes two fundamental stages of error detection—accumulating evidence (input), and reaching a decision (output)—that should be differentially affected by changes in internal criterion Predictions from this model were tested in a brightness discrimination task that required human participants to signal their errors, with incentives varied to encourage participants to adopt a high or low criterion for signaling their errors Whereas the Ne/ERN was unaffected by this manipulation, the Pe varied consistently with criterion: A higher criterion was associated with larger Pe amplitude for signaled errors, suggesting that the Pe reflects the strength of accumulated evidence Across participants, Pe amplitude was predictive of changes in behavioral criterion as estimated through signal detection theory analysis Within participants, Pe amplitude could be estimated robustly with multivariate machine learning techniques and used to predict error signaling behavior both at the level of error signaling frequencies and at the level of individual signaling responses These results suggest that the Pe, rather than the Ne/ERN, is closely related to error detection, and specifically reflects the accumulated evidence that an error has been committed

253 citations

Journal ArticleDOI
TL;DR: It is shown that the chaperone-associated ubiquitin ligase CHIP is able to induce the proteasomal degradation of p53, and that mutant and wild-type p53 transiently associate with molecular chaperones and can be diverted onto a degradation pathway through this association.

253 citations

Journal ArticleDOI
TL;DR: The ability to oxidize ferrous iron anaerobically with nitrate at approximately pH 7 appears to be a widespread capacity among mesophilic denitrifying bacteria.
Abstract: Nine out of ten anaerobic enrichment cultures inoculated with sediment samples from various freshwater, brackish-water, and marine sediments exhibited ferrous iron oxidation in mineral media with nitrate and an organic cosubstrate at pH 7.2 and 30° C. Anaerobic nitrate-dependent ferrous iron oxidation was a biological process. One strain isolated from brackish-water sediment (strain HidR2, a motile, nonsporeforming, gram-negative rod) was chosen for further investigation of ferrous iron oxidation in the presence of acetate as cosubstrate. Strain HidR2 oxidized between 0.7 and 4.9 mM ferrous iron aerobically and anaerobically at pH 7.2 and 30° C in the presence of small amounts of acetate (between 0.2 and 1.1 mM). The strain gained energy for growth from anaerobic ferrous iron oxidation with nitrate, and the ratio of iron oxidized to acetate provided was constant at limiting acetate supply. The ability to oxidize ferrous iron anaerobically with nitrate at approximately pH 7 appears to be a widespread capacity among mesophilic denitrifying bacteria. Since nitrate-dependent iron oxidation closes the iron cycle within the anoxic zone of sediments and aerobic iron oxidation enhances the reoxidation of ferrous to ferric iron in the oxic zone, both processes increase the importance of iron as a transient electron carrier in the turnover of organic matter in natural sediments.

252 citations

Journal ArticleDOI
17 Sep 1999-Science
TL;DR: A microscopic method was developed that uses elastic optical waveguides to visualize and measure forces locally exerted by single appressoria of C. graminicola, and found the force exerted was about 17 micronewtons.
Abstract: Many plant pathogenic fungi, such as the cereal pathogen Colletotrichum graminicola, differentiate highly specialized infection structures called appressoria, which send a penetration peg into the underlying plant cell. Appressoria have been shown to generate enormous turgor pressure, but direct evidence for mechanical infection of plants by fungi is lacking. A microscopic method was developed that uses elastic optical waveguides to visualize and measure forces locally exerted by single appressoria. By this method, the force exerted by appressoria of C. graminicola was found to be about 17 micronewtons.

252 citations

Journal ArticleDOI
TL;DR: It is shown that an isolated population from Batang Toru, at the southernmost range limit of extantSumatran orangutans south of Lake Toba, is distinct from other northern Sumatran and Bornean populations, and a new species, Pongo tapanuliensis, is identified.

252 citations


Authors

Showing all 12272 results

NameH-indexPapersCitations
Robert E. W. Hancock15277588481
Lloyd J. Old152775101377
Andrew White1491494113874
Stefanie Dimmeler14757481658
Rudolf Amann14345985525
Niels Birbaumer14283577853
Thomas P. Russell141101280055
Emmanuelle Perez138155099016
Shlomo Havlin131101383347
Bruno S. Frey11990065368
Roald Hoffmann11687059470
Michael G. Fehlings116118957003
Yves Van de Peer11549461479
Axel Meyer11251151195
Manuela Campanelli11167548563
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202360
2022202
20211,361
20201,299
20191,166
20181,082