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Showing papers by "University of Konstanz published in 2016"


Journal ArticleDOI
TL;DR: Several actions could improve the research landscape: developing a common evaluation framework, agreement on the information to include in research papers, a stronger focus on non-accuracy aspects and user modeling, a platform for researchers to exchange information, and an open-source framework that bundles the available recommendation approaches.
Abstract: In the last 16 years, more than 200 research articles were published about research-paper recommender systems. We reviewed these articles and present some descriptive statistics in this paper, as well as a discussion about the major advancements and shortcomings and an overview of the most common recommendation concepts and approaches. We found that more than half of the recommendation approaches applied content-based filtering (55 %). Collaborative filtering was applied by only 18 % of the reviewed approaches, and graph-based recommendations by 16 %. Other recommendation concepts included stereotyping, item-centric recommendations, and hybrid recommendations. The content-based filtering approaches mainly utilized papers that the users had authored, tagged, browsed, or downloaded. TF-IDF was the most frequently applied weighting scheme. In addition to simple terms, n-grams, topics, and citations were utilized to model users' information needs. Our review revealed some shortcomings of the current research. First, it remains unclear which recommendation concepts and approaches are the most promising. For instance, researchers reported different results on the performance of content-based and collaborative filtering. Sometimes content-based filtering performed better than collaborative filtering and sometimes it performed worse. We identified three potential reasons for the ambiguity of the results. (A) Several evaluations had limitations. They were based on strongly pruned datasets, few participants in user studies, or did not use appropriate baselines. (B) Some authors provided little information about their algorithms, which makes it difficult to re-implement the approaches. Consequently, researchers use different implementations of the same recommendations approaches, which might lead to variations in the results. (C) We speculated that minor variations in datasets, algorithms, or user populations inevitably lead to strong variations in the performance of the approaches. Hence, finding the most promising approaches is a challenge. As a second limitation, we noted that many authors neglected to take into account factors other than accuracy, for example overall user satisfaction. In addition, most approaches (81 %) neglected the user-modeling process and did not infer information automatically but let users provide keywords, text snippets, or a single paper as input. Information on runtime was provided for 10 % of the approaches. Finally, few research papers had an impact on research-paper recommender systems in practice. We also identified a lack of authority and long-term research interest in the field: 73 % of the authors published no more than one paper on research-paper recommender systems, and there was little cooperation among different co-author groups. We concluded that several actions could improve the research landscape: developing a common evaluation framework, agreement on the information to include in research papers, a stronger focus on non-accuracy aspects and user modeling, a platform for researchers to exchange information, and an open-source framework that bundles the available recommendation approaches.

648 citations


Journal ArticleDOI
07 Oct 2016-Science
TL;DR: A mesoscale “assembly-and-mineralization” approach inspired by the natural process in mollusks is described to fabricate bulk synthetic nacre that highly resembles both the chemical composition and the hierarchical structure of natural nacre.
Abstract: Although biomimetic designs are expected to play a key role in exploring future structural materials, facile fabrication of bulk biomimetic materials under ambient conditions remains a major challenge. Here, we describe a mesoscale “assembly-and-mineralization” approach inspired by the natural process in mollusks to fabricate bulk synthetic nacre that highly resembles both the chemical composition and the hierarchical structure of natural nacre. The millimeter-thick synthetic nacre consists of alternating organic layers and aragonite platelet layers (91 weight percent) and exhibits good ultimate strength and fracture toughness. This predesigned matrix-directed mineralization method represents a rational strategy for the preparation of robust composite materials with hierarchically ordered structures, where various constituents are adaptable, including brittle and heat-labile materials.

628 citations


Journal ArticleDOI
TL;DR: In this article, the authors sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD).
Abstract: To connect human biology to fish biomedical models, we sequenced the genome of spotted gar (Lepisosteus oculatus), whose lineage diverged from teleosts before teleost genome duplication (TGD). The slowly evolving gar genome has conserved in content and size many entire chromosomes from bony vertebrate ancestors. Gar bridges teleosts to tetrapods by illuminating the evolution of immunity, mineralization and development (mediated, for example, by Hox, ParaHox and microRNA genes). Numerous conserved noncoding elements (CNEs; often cis regulatory) undetectable in direct human-teleost comparisons become apparent using gar: functional studies uncovered conserved roles for such cryptic CNEs, facilitating annotation of sequences identified in human genome-wide association studies. Transcriptomic analyses showed that the sums of expression domains and expression levels for duplicated teleost genes often approximate the patterns and levels of expression for gar genes, consistent with subfunctionalization. The gar genome provides a resource for understanding evolution after genome duplication, the origin of vertebrate genomes and the function of human regulatory sequences.

494 citations


Book ChapterDOI
20 Nov 2016
TL;DR: In computer vision communities such as stereo, optical flow, or visual tracking, commonly accepted and widely used benchmarks have enabled objective comparison and boosted scientific progress.
Abstract: In computer vision communities such as stereo, optical flow, or visual tracking, commonly accepted and widely used benchmarks have enabled objective comparison and boosted scientific progress.

414 citations


Journal ArticleDOI
TL;DR: This exercise assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish, and shows that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates.
Abstract: It is a golden age for animal movement studies and so an opportune time to assess priorities for future work. We assembled 40 experts to identify key questions in this field, focussing on marine megafauna, which include a broad range of birds, mammals, reptiles, and fish. Research on these taxa has both underpinned many of the recent technical developments and led to fundamental discoveries in the field. We show that the questions have broad applicability to other taxa, including terrestrial animals, flying insects, and swimming invertebrates, and, as such, this exercise provides a useful roadmap for targeted deployments and data syntheses that should advance the field of movement ecology.

375 citations


Journal ArticleDOI
TL;DR: An overview of recent advances in XL-MS, the current state of the field, and a cursory outlook on future challenges is provided.

336 citations


Journal ArticleDOI
TL;DR: In this paper, the authors review and provide a perspective on the issues pertaining progress in materials, processes, devices, industrialization and costs of flexible perovskite solar cells.
Abstract: Perovskite solar cells have attracted enormous interest since their discovery only a few years ago because they are able to combine the benefits of high efficiency and remarkable ease of processing over large areas. Whereas most of research has been carried out on glass, perovskite deposition and synthesis is carried out at low temperatures (<150 °C) to convert precursors into its final semiconducting form. Thus, developing the technology on flexible substrates can be considered a suitable and exciting arena both from the manufacturing view point (e.g. web processing, low embodied energy manufacturing) and that of the applications (e.g. flexible, lightweight, portable, easy to integrate over both small, large and curved surfaces). Research has been accelerating on flexible PSCs and has achieved notable milestones including PCEs of 15.6% on laboratory cells, the first modules being manufactured, ultralight cells with record power per gram ratios, and even cells made on fibres. Reviewing the literature, it becomes apparent that more work can be carried out in closing the efficiency gap with glass based counterparts especially at the large-area module level and, in particular, investigating and improving the lifetime of these devices which are built on inherently permeable plastic films. Here we review and provide a perspective on the issues pertaining progress in materials, processes, devices, industrialization and costs of flexible perovskite solar cells.

332 citations


Journal ArticleDOI
TL;DR: Investigations funded by the Deutsche Forschungsgemeinschaft on the anaerobic microbial degradation of hydrocarbons ranged from isolation and enrichment of hitherto unknown hydrocarbon-degrading anaerobe microorganisms, discovery of novel reactions, detailed studies of enzyme mechanisms and structures to process-oriented in situ studies.
Abstract: Hydrocarbons are abundant in anoxic environments and pose biochemical challenges to their anaerobic degradation by microorganisms. Within the framework of the Priority Program 1319, investigations fun

279 citations


Journal ArticleDOI
TL;DR: The status quo of microphysiological systems available today against industry needs is reviewed, and the broad variety of approaches with fit-for-purpose potential in the drug development cycle are assessed, and feasibility solutions to reach the next levels of human biology in vitro are proposed.
Abstract: The recent advent of microphysiological systems - microfluidic biomimetic devices that aspire to emulate the biology of human tissues, organs and circulation in vitro - is envisaged to enable a global paradigm shift in drug development An extraordinary US governmental initiative and various dedicated research programs in Europe and Asia have led recently to the first cutting-edge achievements of human single-organ and multi-organ engineering based on microphysiological systems The expectation is that test systems established on this basis would model various disease stages, and predict toxicity, immunogenicity, ADME profiles and treatment efficacy prior to clinical testing Consequently, this technology could significantly affect the way drug substances are developed in the future Furthermore, microphysiological system-based assays may revolutionize our current global programs of prioritization of hazard characterization for any new substances to be used, for example, in agriculture, food, ecosystems or cosmetics, thus, replacing laboratory animal models used currently Thirty-six experts from academia, industry and regulatory bodies present here the results of an intensive workshop (held in June 2015, Berlin, Germany) They review the status quo of microphysiological systems available today against industry needs, and assess the broad variety of approaches with fit-for-purpose potential in the drug development cycle Feasible technical solutions to reach the next levels of human biology in vitro are proposed Furthermore, key organ-on-a-chip case studies, as well as various national and international programs are highlighted Finally, a roadmap into the future is outlined, to allow for more predictive and regulatory-accepted substance testing on a global scale

235 citations


Journal ArticleDOI
TL;DR: The 1980s regime shift represented a major change in the Earth's biophysical systems from the upper atmosphere to the depths of the ocean and from the Arctic to the Antarctic, and occurred at slightly different times around the world.
Abstract: Despite evidence from a number of Earth systems that abrupt temporal changes known as regime shifts are important, their nature, scale and mechanisms remain poorly documented and understood. Applying principal component analysis, change-point analysis and a sequential t-test analysis of regime shifts to 72 time series, we confirm that the 1980s regime shift represented a major change in the Earth's biophysical systems from the upper atmosphere to the depths of the ocean and from the Arctic to the Antarctic, and occurred at slightly different times around the world. Using historical climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) and statistical modelling of historical temperatures, we then demonstrate that this event was triggered by rapid global warming from anthropogenic plus natural forcing, the latter associated with the recovery from the El Chichon volcanic eruption. The shift in temperature that occurred at this time is hypothesized as the main forcing for a cascade of abrupt environmental changes. Within the context of the last century or more, the 1980s event was unique in terms of its global scope and scale; our observed consequences imply that if unavoidable natural events such as major volcanic eruptions interact with anthropogenic warming unforeseen multiplier effects may occur.

233 citations


Journal ArticleDOI
TL;DR: It is found that hippocampal theta power during encoding predicts subsequent memory integration and increased theta coherence between hippocampus and mPFC, and these findings have important implications for the understanding of memory-based decision making and knowledge acquisition.

Journal ArticleDOI
TL;DR: The methodological progress in the field is contrasted with the actual successful application of the newly developed methods to the synthesis of complex structures to pinpoint the urgent requirement for further synthetic development for efficient synthetic design of this "privileged" structure motif.
Abstract: ConspectusSeven-membered rings fused with an indole are termed cyclohepta[b]indoles. Compounds exhibiting this structure motif display a broad spectrum of biological activities, ranging from inhibition of adipocyte fatty-acid-binding protein (A-FABP), deacetylation of histones, inhibition of leukotriene production p53, antituberculosis activities, and anti-HIV activities. These biological profiles are found in natural products containing the cyclohepta[b]indole motif, as well as in pharmaceuticals that contain this structure motif. Therefore, the biology of molecules derived from the skeleton of cyclohepta[b]indoles, as well as cyclopenta- and cyclohexa[b]indoles, has attracted considerable interest from the pharmaceutical industry as potential therapeutics in recent years. This is reflected by more than two dozen patents that have been issued in the past decade, solely based on the cyclohepta[b]indole structure motif. The efficient preparation of highly functionalized and unsymmetrically substituted cycl...

Journal ArticleDOI
TL;DR: Developments in the CrystFEL software suite, for processing diffraction data from ‘serial crystallography’ experiments, are described.
Abstract: CrystFEL is a suite of programs for processing data from `serial crystallography' experiments, which are usually performed using X-ray free-electron lasers (FELs) but also increasingly with other X-ray sources. The CrystFEL software suite has been under development since 2009, just before the first hard FEL experiments were performed, and has been significantly updated and improved since then. This article describes the most important improvements which have been made to CrystFEL since the first release version. These changes include the addition of new programs to the suite, the ability to resolve `indexing ambiguities' and several ways to improve the quality of the integrated data by more accurately modelling the underlying diffraction physics.

Journal ArticleDOI
TL;DR: In this paper, the authors developed four-item scales for three emotions considered most relevant in the context of teaching: enjoyment, anger, and anxiety (Teacher Emotions Scales, TES).

Journal ArticleDOI
TL;DR: The authors found that an increase in job crafting at time 2 was predicted by need for positive self-image (Time 1), as well as by work experience (Time 2), and need for human connection was related to job crafting when self-efficacy was high.
Abstract: As a proactive behavior, job crafting refers to changes in the task (cognitive, and behavioral) and social boundaries at work. This article focuses on antecedents of job crafting and the development and validation of a job crafting scale. In Study 1 (N = 466), an exploratory factor analysis with one half of the sample (n = 233) and a confirmatory factor analysis with the other half (n = 233) supported a three-dimensional structure of job crafting (task crafting, relational crafting and cognitive crafting), and convergent as well as discriminant validity of job crafting, in relation to personal initiative and organizational citizenship behavior. In Study 2 (N = 118, two points of measurement), we cross-validated the measure and demonstrated that job crafting was related to, yet distinct from, taking charge. We found that an increase in job crafting at Time 2 was predicted by need for positive self-image (Time 1), as well as by work experience (Time 1). Need for human connection (Time 1) was related to job crafting at Time 2 when self-efficacy was high. Moreover, there was evidence that job crafting as self-oriented behavior related positively to person–job fit. Implications for future research are discussed.

Journal ArticleDOI
TL;DR: A comprehensive account is given of long-chain monomer syntheses and the preparation and physical properties, morphologies, mechanical behavior, and degradability ofLong-chain polyester, polyamides, polyurethanes,polyureas, polyacetals, and polycarbonates.
Abstract: Other than their established short-chain congeners, polycondensates based on long-chain difunctional monomers are often dominated by the long methylene sequences of the repeat units in their solid-state structures and properties. This places them between traditional polycondensates and polyethylenes. The availability of long-chain monomers as a key prerequisite has benefited much from advances in the catalytic conversion of plant oils, via biotechnological and purely chemical approaches, likewise. This has promoted studies of, among others, applications-relevant properties. A comprehensive account is given of long-chain monomer syntheses and the preparation and physical properties, morphologies, mechanical behavior, and degradability of long-chain polyester, polyamides, polyurethanes, polyureas, polyacetals, and polycarbonates.

Journal ArticleDOI
TL;DR: In this article, the authors present a quantitative assessment of reporting bias in a micro-level analysis of media-based event reports and those from military sources, showing that the purported violence-increasing effect of cellphone coverage is partly due to higher reporting rates of violence in cellphone-covered areas.
Abstract: Recent data collections about political violence are frequently based on media reports, which can lead to reporting bias. This is an issue in particular for the emergent literature on communication technology and conflict, since this technology may not only affect violence, but also the reporting about it. Using the effect of cellphones on violence as an example, this article presents a quantitative assessment of reporting bias in a micro-level analysis. Comparing media-based event reports and those from military sources, the results show that the purported violence-increasing effect of cellphone coverage is partly due to higher reporting rates of violence in cellphone-covered areas. A simple diagnostic procedure for this problem is implemented. Applied to the analysis of cellphones and violence in Africa, it produces a pattern that is consistent with reporting bias driving much of the effect found in the Pierskalla and Hollenbach (2013) study about this topic.

Journal ArticleDOI
TL;DR: Results indicate augmented vulnerability by type x timing of ACE, in particular emphasizing pre-school and pre-adolescent periods as sensitive for the impact of physical and emotional neglect.
Abstract: A dose-dependent effect of Adverse Childhood Experiences (ACE) on the course and severity of psychiatric disorders has been frequently reported. Recent evidence indicates additional impact of type and timing of distinct ACE on symptom severity experienced in adulthood, in support of stress-sensitive periods in (brain) development. The present study seeks to clarify the impact of ACE on symptoms that are often comorbid across various diagnostic groups: symptoms of posttraumatic stress disorder (PTSD), shutdown dissociation and depression. A key aim was to determine and compare the importance of dose-dependent versus type and timing specific prediction of ACE on symptom levels. Exposure to ten types of maltreatment up to age 18 were retrospectively assessed in N = 129 psychiatric inpatients using the Maltreatment and Abuse Chronology of Exposure (MACE). Symptoms of PTSD, shutdown dissociation, and depression were related to type and timing of ACE. The predictive power of peak types and timings was compared to that of global MACE measures of duration, multiplicity and overall severity. A dose-dependent effect (MACE duration, multiplicity and overall severity) on severity of all symptoms confirmed earlier findings. Conditioned random forest regression verified that PTSD symptoms were best predicted by overall ACE severity, whereas type and timing specific effects showed stronger prediction for symptoms of dissociation and depression. In particular, physical neglect at age 5 and emotional neglect at ages 4–5 were related to increased symptoms of dissociation, whereas the emotional neglect at age 8–9 enhanced symptoms of depression. In support of the sensitive period of exposure model, present results indicate augmented vulnerability by type x timing of ACE, in particular emphasizing pre-school (age 4–5) and pre-adolescent (8–9) periods as sensitive for the impact of physical and emotional neglect. PTSD, the most severe stress-related disorder, varies with the amount of adverse experiences irrespective of age of experience. Considering type and timing of ACE improves understanding of vulnerability, and should inform diagnostics of psychopathology like PTSD, dissociation and depression in adult psychiatric patients.

Journal ArticleDOI
TL;DR: In this paper, the authors present an implementation of smoothed particle hydrodynamics (SPH) with improved accuracy for simulations of galaxies and the large-scale structure, and demonstrate that the new implementation overcomes most of the undesirable limitations of standard GADGET-SPH.
Abstract: We present an implementation of smoothed particle hydrodynamics (SPH) with improved accuracy for simulations of galaxies and the large-scale structure. In particular, we implement and test a vast majority of SPH improvement in the developer version of GADGET-3. We use the Wendland kernel functions, a particle wake-up time-step limiting mechanism and a time-dependent scheme for artificial viscosity including high-order gradient computation and shear flow limiter. Additionally, we include a novel prescription for time-dependent artificial conduction, which corrects for gravitationally induced pressure gradients and improves the SPH performance in capturing the development of gas-dynamical instabilities. We extensively test our new implementation in a wide range of hydrodynamical standard tests including weak and strong shocks as well as shear flows, turbulent spectra, gas mixing, hydrostatic equilibria and self-gravitating gas clouds. We jointly employ all modifications;however, when necessary we study the performance of individual code modules. We approximate hydrodynamical states more accurately and with significantly less noise than standard GADGET-SPH. Furthermore, the new implementation promotes the mixing of entropy between different fluid phases, also within cosmological simulations. Finally, we study the performance of the hydrodynamical solver in the context of radiative galaxy formation and non-radiative galaxy cluster formation. We find galactic discs to be colder and more extended and galaxy clusters showing entropy cores instead of steadily declining entropy profiles. In summary, we demonstrate that our improved SPH implementation overcomes most of the undesirable limitations of standard GADGET-SPH, thus becoming the core of an efficient code for large cosmological simulations.

Journal ArticleDOI
TL;DR: In this article, the carrier envelope-phase control of the electronic current over a laterally confined tunnelling gap a few nanometres wide yields current densities above 50 MA cm 2 driven by picojoule-level optical pulses at room temperature.
Abstract: Carrier-envelope-phase control of the electronic current over a laterally confined tunnelling gap a few nanometres wide yields current densities above 50 MA cm–2 driven by picojoule-level optical pulses at room temperature.

Journal ArticleDOI
TL;DR: The data suggest the HopQ–CEACAM1 interaction to be a potentially promising novel therapeutic target to combat H. pylori-associated diseases.
Abstract: Helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. Here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as receptors of H. pylori and show that HopQ is the surface-exposed adhesin that specifically binds human CEACAM1, CEACAM3, CEACAM5 and CEACAM6. HopQ-CEACAM binding is glycan-independent and targeted to the N-domain. H. pylori binding induces CEACAM1-mediated signalling, and the HopQ-CEACAM1 interaction enables translocation of the virulence factor CagA into host cells and enhances the release of pro-inflammatory mediators such as interleukin-8. Based on the crystal structure of HopQ, we found that a β-hairpin insertion (HopQ-ID) in HopQ's extracellular 3+4 helix bundle domain is important for CEACAM binding. A peptide derived from this domain competitively inhibits HopQ-mediated activation of the Cag virulence pathway, as genetic or antibody-mediated abrogation of the HopQ function shows. Together, our data suggest the HopQ-CEACAM1 interaction to be a potentially promising novel therapeutic target to combat H. pylori-associated diseases.

Journal ArticleDOI
TL;DR: In this article, the authors assess the state of the art of nanophononics, describing the recent achievements and the open challenges in nanoscale heat transport, coherent phonon generation and exploitation, and in nano- and optomechanics.
Abstract: Understanding and controlling vibrations in condensed matter is emerging as an essential necessity both at fundamental level and for the development of a broad variety of technological applications. Intelligent design of the band structure and transport properties of phonons at the nanoscale and of their interactions with electrons and photons impact the efficiency of nanoelectronic systems and thermoelectric materials, permit the exploration of quantum phenomena with micro- and nanoscale resonators, and provide new tools for spectroscopy and imaging. In this colloquium we assess the state of the art of nanophononics, describing the recent achievements and the open challenges in nanoscale heat transport, coherent phonon generation and exploitation, and in nano- and optomechanics. We also underline the links among the diverse communities involved in the study of nanoscale phonons, pointing out the common goals and opportunities.

Journal ArticleDOI
TL;DR: A facile route for an amorphous CaCO3 (ACC)-based hydrogel consisting of very small ACC nanoparticles physically cross-linked by poly(acrylic acid) is reported, which may represent a new class of plastic materials, the "mineral plastics".
Abstract: Given increasing environmental issues due to the large usage of non-biodegradable plastics based on petroleum, new plastic materials, which are economic, environmentally friendly, and recyclable are in high demand. One feasible strategy is the bio-inspired synthesis of mineral-based hybrid materials. Herein we report a facile route for an amorphous CaCO3 (ACC)-based hydrogel consisting of very small ACC nanoparticles physically cross-linked by poly(acrylic acid). The hydrogel is shapeable, stretchable, and self-healable. Upon drying, the hydrogel forms free-standing, rigid, and transparent objects with remarkable mechanical performance. By swelling in water, the material can completely recover the initial hydrogel state. As a matrix, thermochromism can also be easily introduced. The present hybrid hydrogel may represent a new class of plastic materials, the "mineral plastics".

Journal ArticleDOI
TL;DR: A review of teacher enthusiasm research can be found in this paper, which provides a potential starting point for a new, consolidated direction in teacher enthusiasm based on a proposed, holistic definition of enthusiasm which brings together research from the past and can fuel research for the future.
Abstract: The last review on teacher enthusiasm was 45 years ago, and teacher enthusiasm remains a compelling yet complex variable in the educational context. Since Rosenshine's (School Review 78:499-514, 1970) review, the conceptualizations, definitions, methodology, and results have only become more scattered, and several related constructs have emerged that may or may not be synonymous with teacher enthusiasm. In this review, we delve into the past four decades of teacher enthusiasm research to provide a potential starting point for a new, consolidated direction in teacher enthusiasm research based on a proposed, holistic definition of enthusiasm which brings together research from the past and can fuel research for the future. We begin by reviewing definitions of teacher enthusiasm and related constructs and, thereafter, put forward a new and integrative definition of teacher enthusiasm that combines the two most prevalent conceptualizations of the construct, namely experienced enjoyment and expressive behavior. Bearing our proposed definition in mind, we go on to present numerous measures that assess teacher enthusiasm, detail research evidence related to its correlates, and finally derive several research implications that, when considered in future research, promise to advance the field.

Journal ArticleDOI
TL;DR: The Synergy Expert Group comprised world-leading researchers in health and social psychology and behavioural medicine who convened to discuss priority issues in planning interventions in health contexts and develop a set of recommendations for future research and practice.
Abstract: The current article details a position statement and recommendations for future research and practice on planning and implementation intentions in health contexts endorsed by the Synergy Expert Group. The group comprised world-leading researchers in health and social psychology and behavioural medicine who convened to discuss priority issues in planning interventions in health contexts and develop a set of recommendations for future research and practice. The expert group adopted a nominal groups approach and voting system to elicit and structure priority issues in planning interventions and implementation intentions research. Forty-two priority issues identified in initial discussions were further condensed to 18 key issues, including definitions of planning and implementation intentions and 17 priority research areas. Each issue was subjected to voting for consensus among group members and formed the basis of the position statement and recommendations. Specifically, the expert group endorsed statements and recommendations in the following areas: generic definition of planning and specific definition of implementation intentions, recommendations for better testing of mechanisms, guidance on testing the effects of moderators of planning interventions, recommendations on the social aspects of planning interventions, identification of the preconditions that moderate effectiveness of planning interventions and recommendations for research on how people use plans.

Journal ArticleDOI
06 Jun 2016
TL;DR: The goal of this survey is to provide a comprehensive list of reordering algorithms published in different fields such as statistics, bioinformatics, or graph theory to enable a wide audience to understand their differences and subtleties.
Abstract: This survey provides a description of algorithms to reorder visual matrices of tabular data and adjacency matrix of networks. The goal of this survey is to provide a comprehensive list of reordering algorithms published in different fields such as statistics, bioinformatics, or graph theory. While several of these algorithms are described in publications and others are available in software libraries and programs, there is little awareness of what is done across all fields. Our survey aims at describing these reordering algorithms in a unified manner to enable a wide audience to understand their differences and subtleties. We organize this corpus in a consistent manner, independently of the application or research field. We also provide practical guidance on how to select appropriate algorithms depending on the structure and size of the matrix to reorder, and point to implementations when available.

Journal ArticleDOI
15 Dec 2016-Nature
TL;DR: The sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes is reported and it is found that the H. comes genome lacks enamel matrix protein-coding proline/glutamine-rich secretory calcium-binding phosphoprotein genes, which might have led to the loss of mineralized teeth.
Abstract: Seahorses have a specialized morphology that includes a toothless tubular mouth, a body covered with bony plates, a male brood pouch, and the absence of caudal and pelvic fins. Here we report the sequencing and de novo assembly of the genome of the tiger tail seahorse, Hippocampus comes. Comparative genomic analysis identifies higher protein and nucleotide evolutionary rates in H. comes compared with other teleost fish genomes. We identified an astacin metalloprotease gene family that has undergone expansion and is highly expressed in the male brood pouch. We also find that the H. comes genome lacks enamel matrix protein-coding proline/glutamine-rich secretory calcium-binding phosphoprotein genes, which might have led to the loss of mineralized teeth. tbx4, a regulator of hindlimb development, is also not found in H. comes genome. Knockout of tbx4 in zebrafish showed a 'pelvic fin-loss' phenotype similar to that of seahorses.

Journal ArticleDOI
TL;DR: It is proposed a variant notion of distance that maintains the duality of closeness-as-independence with betweenness also on valued relations.

Journal ArticleDOI
TL;DR: This study adds unpublished data to the odor-response profiles for four odorant receptors and deorphanizes Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool.
Abstract: Odors elicit complex patterns of activated olfactory sensory neurons. Knowing the complete olfactome, i.e. the responses in all sensory neurons for all relevant odorants, is desirable to understand olfactory coding. The DoOR project combines all available Drosophila odorant response data into a single consensus response matrix. Since its first release many studies were published: receptors were deorphanized and several response profiles were expanded. In this study, we add unpublished data to the odor-response profiles for four odorant receptors (Or10a, Or42b, Or47b, Or56a). We deorphanize Or69a, showing a broad response spectrum with the best ligands including 3-hydroxyhexanoate, alpha-terpineol, 3-octanol and linalool. We include all of these datasets into DoOR, provide a comprehensive update of both code and data, and new tools for data analyses and visualizations. The DoOR project has a web interface for quick queries (http://neuro.uni.kn/DoOR), and a downloadable, open source toolbox written in R, including all processed and original datasets. DoOR now gives reliable odorant-responses for nearly all Drosophila olfactory responding units, listing 693 odorants, for a total of 7381 data points.

Journal ArticleDOI
TL;DR: A phylogenetically controlled meta-analysis to compare invasive and native plant species for differences in the frequency and magnitude of local adaptation found that local plants performed better than foreign plants, and invasive plant species expressed local adaptation just as frequently, and at least as strongly as that exhibited by native plants.
Abstract: Summary Concerns over the ecological impacts of invasive alien plant species have generated great research interest in understanding the mechanisms that underlie the capacity of such plants to occupy a broad range of habitats. It has been repeatedly suggested that rapid evolution of local adaptation to novel environments may enable invasive plants to occupy a broad range of habitats. However, the classical Darwinian view on evolution by natural selection is that the process is slow and gradual, occurring over thousands of years. Invasive plants typically have a relatively short residence time in their introduced ranges (decades or just a few centuries). Besides the time constraint, founder effects (reduction in population size and genetic diversity) may also limit the capacity of invasive plants to rapidly evolve local adaption. Thus, invasive plants may be less likely than native plants to evolve local adaptation. Interestingly, however, an expanding body of literature documents the existence of local adaptation in invasive plant species within their exotic ranges. Here, we did a phylogenetically controlled meta-analysis to compare invasive and native plant species for differences in the frequency and magnitude of local adaptation. The meta-analysis was based on different experiments performed in various habitats including grasslands, steppes, deserts, forests, mountains, wetlands and dunes, and used a total of 134 plant species in 52 families. Forty seven of these species (in 24 families) are alien invaders in the region where the studies were undertaken, while the other 91 species (in 38 families) are native. On average, local plants performed better than foreign plants, and invasive plant species expressed local adaptation just as frequently, and at least as strongly as that exhibited by native plant species. An analysis performed while taking into account different plant life-history traits showed that self-incompatible invasive plants exhibited significantly higher frequencies of local adaptation than native plants characterized by the same breeding system. Synthesis. The present results support the suggestion that rapid evolution of local adaptation may enable invasive plant species to occupy a broad range of novel habitats.