University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

Systematic review with network meta-analysis: comparative assessment of tofacitinib and biological therapies for moderate-to-severe ulcerative colitis

Abstract: Background Biological therapies have improved the care of patients with ulcerative colitis (UC). Tofacitinib, an oral small-molecule Janus kinase inhibitor, is potentially a new treatment option. Aim To comparatively assess efficacy and harm of tofacitinib and biologics (infliximab, adalimumab, golimumab and vedolizumab) in adult patients not previously exposed to TNF antagonists. Methods We performed a comprehensive search of PubMed, Embase, Scopus, clinical trial registries, regulatory authorities' websites and major conference proceedings, through August 2017, to identify randomised, placebo-controlled or head-to-head trials assessing tofacitinib or biologics as induction and/or maintenance therapy in moderate-to-severe UC. Two reviewers independently extracted study data and outcomes, and investigated each trial's risk-of-bias. We used conventional meta-analysis to synthesise direct evidence, and network meta-analysis for adjusted indirect treatment comparisons. Results Fifteen randomised, double-blind, placebo-controlled trials (n = 3130) contributed data for induction: All treatments are superior to placebo. Indirect treatment comparisons showed that infliximab is better than adalimumab (OR: 2.01, 95% CI: 1.36-2.98) and golimumab (1.67, 1.08-2.59) in clinical response, better than adalimumab (2.10, 1.21-3.64) in clinical remission, and better than adalimumab (1.87, 1.26-2.79) and golimumab (1.75, 1.13-2.73) in mucosal healing. No indirect comparisons between tofacitinib and biologics reached statistical significance. Nine studies (n = 1776) contributed maintenance data showing that all treatments have higher clinical efficacy than placebo. Safety analyses indicated no increased rates of adverse events for the treatments under evaluation (except for infliximab), while vedolizumab may have an advantage regarding the occurrence of serious adverse events. Conclusions Tofacitinib and biologics are efficacious and safe for UC. Further high-quality research is warranted to establish the best therapeutic option.

Crop–livestock integration beyond the farm level: a review

Abstract: Paradoxically, the number of crop–livestock farms is declining across Europe, despite the fact that crop-livestock farms are theoretically optimal to improve the sustainability of agriculture. To solve this issue, crop–livestock integration may be organized beyond the farm level. For instance, local groups of farmers can negotiate land-use allocation patterns and exchange materials such as manure, grain, and straw. Development of such a collective agricultural system raises questions, rarely documented in the literature, about how to integrate crops and livestock among farms, and the consequences, impacts, and conditions of integrating them. Here, we review the different forms of crop–livestock integration beyond the farm level, their potential benefits, and the features of decision support systems (DSS) needed for the integration process. We identify three forms of crop–livestock integration beyond the farm level: local coexistence, complementarity, and synergy, each with increasingly stronger temporal, spatial, and organizational coordination among farms. We claim that the forms of integration implemented define the nature, area, and spatial configuration of crops, grasslands, and animals in farms and landscapes. In turn, these configurations influence the provision of ecosystem services. For instance, we show that the synergy form of integration promotes soil fertility, erosion control, and field-level biological regulation services through organizational coordination among farmers and spatiotemporal integration between crops, grasslands, and animals. We found that social benefits of the synergy form of integration include collective empowerment of farmers. We claim that design of the complementarity and synergy forms of crop–livestock integration can best be supported by collective participatory workshops involving farmers, agricultural consultants, and researchers. In these workshops, spatialized simulation modeling of crop–livestock integration among farms is the basis for achieving the upscaling process involved in integrating beyond the farm level. Facilitators of these workshops have to pay attention to the consequences on governance and equity issues within farmers groups.

Exciton and core-level electron confinement effects in transparent ZnO thin films

Abstract: The excitonic light emission of ZnO films have been investigated by means of photoluminescence measurements in ultraviolet-visible region. Exciton confinement effects have been observed in thin ZnO coatings with thickness below 20 nm. This is enhanced by a rise of the intensity and a blue shift of the photoluminescence peak after extraction of the adsorbed species upon annealing in air. It is found experimentally that the free exciton energy (determined by the photoluminescence peak) is inversely proportional to the square of the thickness while core-level binding energy is inversely proportional to the thickness. These findings correlate very well with the theory of kinetic and potential confinements.