University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

Optimisation of laser parameters for the analysis of sulphur isotopes in sulphide minerals by laser ablation ICP-MS

Abstract: The effects of laser type (Nd:YAG and excimer lasers) and their analytical parameters on 34S/32S isotopic fractionation during LA-ICP-MS analysis were investigated. Laser fluence has a larger fractionation effect when ablating pyrite with the New Wave Nd:YAG 193 nm laser, compared to the Resonetics 193 nm excimer laser which did not produce significant fractionation over the same range of fluence (1.3–3.7 J cm−2). Matrix effects occurred between pyrite and bornite on both laser systems, especially at low fluence. However, matrix effects can be reduced with increasing fluence lessening the need for matrix matched reference materials. The effects of interface tubing configuration were also investigated and the addition of a ‘squid’ mixing device, a coil of small diameter Tygon tubing and a small volume glass bulb, was found to improve signal precision and reproducibility and decrease the washout time of the S signal between analyses. The degassing of air from the inner surfaces of the interface tubing can produce significant isotopic drift (8‰ h−1), hence flushing the tubing prior to analyses is crucial for reproducible analyses. The isotopic composition and homogeneity of a range of sulphide minerals were characterised for use as potential reference materials. We present preliminary data for a large, isotopically homogeneous pyrite crystal (PPP-1) which could be considered as a new isotopic reference material (δ34SV-CDT = 5.3 ± 0.2‰).

Pharmacokinetics of adalimumab in inflammatory bowel diseases: a systematic review and meta-analysis.

Abstract: Background:The aim of this meta-analysis was to explore the magnitude of the association between pharmacokinetics of adalimumab and clinical response in patients with inflammatory bowel disease.Methods:A literature search was performed up to December 2013. MEDLINE, EMBASE, Cochrane, and meeting abst

The Role of the FOLFIRINOX Regimen for Advanced Pancreatic Cancer

Abstract: In 2010, the FOLFIRINOX regimen (bolus and infusional 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) emerged as a new option in patients with metastatic pancreatic cancer and a good performance status However, at that time, some doubts were raised regarding safety issues Similarly, no data on FOLFIRINOX were published in patients with unresectable/locally advanced or borderline resectable pancreatic cancer This article presents the available experience with FOLFIRINOX outside clinical trials in metastatic and locally advanced pancreatic cancer patients The safety of the regimen in patients with biliary stents and in previously treated patients is also described FOLFIRINOX usage in clinical practice, including modification of the regimen (omission of bolus 5-fluorouracil; FOLFOXIRI regimen), is also presented These data suggest that a phase III randomized study is warranted to further explore the role of FOLFIRINOX in locally advanced pancreatic cancer