University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

Ethylene Removal and Fresh Product Storage: A Challenge at the Frontiers of Chemistry. Toward an Approach by Photocatalytic Oxidation

Abstract: Frontiers of Chemistry. Toward an Approach by Photocatalytic Oxidation Nicolas Keller,*,† Marie-Noel̈le Ducamp,‡ Didier Robert, and Valeŕie Keller† †Institut de Chimie et Proced́eś pour l’Energie, l’Environnement et la Sante ́ (ICPEES), CNRS, Strasbourg University, 25 rue Becquerel 67087, Strasbourg, France ‡UMR 95 QUALISUD, CIRAD, TA B 95/16, 73 Bd Jean-Franco̧is Breton, 34398 Montpellier Cedex 5, France Saint-Avold Antenna, Institut de Chimie et Proced́eś pour l’Energie, l’Environnement et la Sante ́ (ICPEES), CNRS, Strasbourg University, Universite ́ de Lorraine, rue Victor Demange 57500 Saint-Avold, France

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Abstract: Summary Background General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p Interpretation Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons. Funding Medtronic.

Tracking and fixed ranking of leukocyte telomere length across the adult life course.

Abstract: Short leukocyte telomere length (LTL) is associated with atherosclerosis in adults and diminished survival in the elderly. LTL dynamics are defined by LTL at birth, which is highly variable, and its age-dependent attrition thereafter, which is rapid during the first 20 years of life. We examined whether age-dependent LTL attrition during adulthood can substantially affect individuals' LTL ranking (e.g., longer or shorter LTL) in relation to their peers. We measured LTL in samples donated 12 years apart on average by 1156 participants in four longitudinal studies. We observed correlations of 0.91-0.96 between baseline and follow-up LTLs. Ranking individuals by deciles revealed that 94.1% (95% confidence interval of 92.6-95.4%) showed no rank change or a 1 decile change over time. We conclude that in adults, LTL is virtually anchored to a given rank with the passage of time. Accordingly, the links of LTL with atherosclerosis and longevity appear to be established early in life. It is unlikely that lifestyle and its modification during adulthood exert a major impact on LTL ranking.

Rational extensions of the quantum harmonic oscillator and exceptional Hermite polynomials

Abstract: We prove that every rational extension of the quantum harmonic oscillator that is exactly solvable by polynomials is monodromy free, and therefore can be obtained by applying a finite number of state-deleting Darboux transformations on the harmonic oscillator. Equivalently, every exceptional orthogonal polynomial system of Hermite type can be obtained by applying a Darboux-Crum transformation to the classical Hermite polynomials. Exceptional Hermite polynomial systems only exist for even codimension 2m, and they are indexed by the partitions λ of m. We provide explicit expressions for their corresponding orthogonality weights and differential operators and a separate proof of their completeness. Exceptional Hermite polynomials satisfy a 2l + 3 recurrence relation where l is the length of the partition λ. Explicit expressions for such recurrence relations are given.