University of Lorraine

About: University of Lorraine is a education organization based out in Nancy, France. It is known for research contribution in the topics: Population & Context (language use). The organization has 11942 authors who have published 25010 publications receiving 425227 citations. The organization is also known as: Lorraine University.

Benchmarking hydrological models for low-flow simulation and forecasting on French catchments

Abstract: Low-flow simulation and forecasting remains a difficult issue for hydrological modellers, and intercomparisons can be extremely instructive for assessing existing lowflow prediction models and for developing more efficient operational tools. This research presents the results of a collaborative experiment conducted to compare low-flow simulation and forecasting models on 21 unregulated catchments in France. Five hydrological models (four lumped storagetype models - Gardenia, GR6J, Mordor and Presages - and one distributed physically oriented model - SIM) were applied within a common evaluation framework and assessed using a common set of criteria. Two simple benchmarks describing the average streamflow variability were used to set minimum levels of acceptability for model performance in simulation and forecasting modes. Results showed that, in simulation as well as in forecasting modes, all hydrological models performed almost systematically better than the benchmarks. Although no single model outperformed all the others for all catchments and criteria, a few models appeared to be more satisfactory than the others on average. In simulation mode, all attempts to relate model efficiency to catchment or streamflow characteristics remained inconclusive. In forecasting mode, we defined maximum useful forecasting lead times beyond which the model does not bring useful information compared to the benchmark. This maximum useful lead time logically varies between catchments, but also depends on the model used. Simple multi-model approaches that combine the outputs of the five hydrological models were tested to improve simulation and forecasting efficiency. We found that the multi-model approach was more robust and could provide better performance than individual models on average

Skin testing and patch testing in non-IgE-mediated drug allergy.

Abstract: Drug skin tests can reproduce delayed hypersensitivity to drugs and entail a moderate reexposure of patients to offending drugs. Drug patch tests (DPTs) and prick tests can be done with any commercialized form of a drug. In non-severe delayed non-IgE-mediated reactions to drugs, intradermal tests (IDT) with delayed readings have a greater value, but their techniques lack standardization. A negative drug skin test does not exclude the responsibility of a drug, and the drug must be rechallenged in non-severe cases. DPTs are useful in maculopapular rashes, flexural exanthemas, and if done in situ, also in fixed drug eruption. Their best indication is in acute generalized exanthematous pustulosis or drug reaction with eosinophilia and systemic symptoms (DRESS). They should be carried out cautiously, following strict guidelines. Prick tests have a low value but they can sometimes be positive on delayed readings. In non-severe delayed reactions to drugs, intradermal tests with delayed readings are the most sensitive skin tests especially for beta-lactam antibiotics, radiocontrast media, heparins but also some biological agents. The value of patch testing varies according to the implicated drug and the non-immediate adverse drug reaction. In DRESS, DPTs have a good value in testing carbamazepine or proton pump inhibitors but remain negative in testing with allopurinol or salazopyrin. In toxic epidermal necrolysis, DPTs are safe but positive in only 9 to 23 % of the reported cases.

Blind test of density-functional-based methods on intermolecular interaction energies

Abstract: In the past decade, a number of approaches have been developed to fix the failure of (semi)local density-functional theory (DFT) in describing intermolecular interactions. The performance of several such approaches with respect to highly accurate benchmarks is compared here on a set of separation-dependent interaction energies for ten dimers. Since the benchmarks were unknown before the DFT-based results were collected, this comparison constitutes a blind test of these methods.

Existence and convergence to a propagating terrace in one-dimensional reaction-diffusion equations

Abstract: We consider one-dimensional reaction-diffusion equations for a large class of spatially periodic nonlinearities – including multistable ones – and study the asymptotic behavior of solutions with Heaviside type initial data. Our analysis reveals some new dynamics where the profile of the propagation is not characterized by a single front, but by a layer of several fronts which we call a terrace. Existence and convergence to such a terrace is proven by using an intersection number argument, without much relying on standard linear analysis. Hence, on top of the peculiar phenomenon of propagation that our work highlights, several corollaries will follow on the existence and convergence to pulsating traveling fronts even for highly degenerate nonlinearities that have not been treated before.