University of New Mexico

About: University of New Mexico is a education organization based out in Albuquerque, New Mexico, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28870 authors who have published 64767 publications receiving 2578371 citations. The organization is also known as: UNM & Universitatis Novus Mexico.

Clinical Recommendations for Cardiopulmonary Exercise Testing Data Assessment in Specific Patient Populations

Abstract: From an evidence-based perspective, cardiopulmonary exercise testing (CPX) is a well-supported assessment technique in both the United States (US) and Europe. The combination of standard exercise testing (ET) (ie, progressive exercise provocation in association with serial electrocardiograms [ECG], hemodynamics, oxygen saturation, and subjective symptoms) and measurement of ventilatory gas exchange amounts to a superior method to: 1) accurately quantify cardiorespiratory fitness (CRF), 2) delineate the physiologic system(s) underlying exercise responses, which can be applied as a means to identify the exercise-limiting pathophysiologic mechanism(s) and/or performance differences, and 3) formulate function-based prognostic stratification. Cardiopulmonary ET certainly carries an additional cost as well as competency requirements and is not an essential component of evaluation in all patient populations. However, there are several conditions of confirmed, suspected, or unknown etiology where the data gained from this form of ET is highly valuable in terms of clinical decision making.1 Several CPX statements have been published by well-respected organizations in both the US and Europe.1–5 Despite these prominent reports and the plethora of pertinent medical literature which they feature, underutilization of CPX persists. This discrepancy is at least partly attributable to the fact that the currently available CPX consensus statements are inherently complex and fail to convey succinct, clinically centered strategies to utilize CPX indices effectively. Likewise, current CPX software packages generate an overwhelming abundance of data, which to most clinicians are incomprehensible and abstract. Ironically, in contrast to the protracted scientific statements and dense CPX data outputs, the list of CPX variables that have proven clinical application is concise and uncomplicated. Therefore, the goal of this writing group is to present an approach of CPX in a way that assists in making meaningful decisions regarding a patient’s care. Experts from the European Association for Cardiovascular Prevention and Rehabilitation and American Heart Association have joined in this effort to distill easy-to-follow guidance on CPX interpretation based upon current scientific evidence. This document also provides a series of forms that are designed to highlight the utility of CPX in clinical decision-making. Not only will this improve patient management, it will also catalyze uniform and unambiguous data interpretation across laboratories on an international level. The primary target audience of this position paper is clinicians who have limited orientation with CPX but whose caregiving would be enhanced by familiarity and application of this assessment. The ultimate goal is to increase awareness of the value of CPX and to increase the number of healthcare professionals who are able to perform clinically meaningful CPX interpretation. Moreover, this document will hopefully lead to an increase in appropriate patient referrals to CPX with enhanced efficiencies in patient management. For more detailed information on CPX, including procedures for patient preparation, equipment calibration, and conducting the test, readers are encouraged to review other publications that address these and other topics in great detail.1–5

Random Boolean network models and the yeast transcriptional network

Abstract: The recently measured yeast transcriptional network is analyzed in terms of simplified Boolean network models, with the aim of determining feasible rule structures, given the requirement of stable solutions of the generated Boolean networks. We find that, for ensembles of generated models, those with canalyzing Boolean rules are remarkably stable, whereas those with random Boolean rules are only marginally stable. Furthermore, substantial parts of the generated networks are frozen, in the sense that they reach the same state, regardless of initial state. Thus, our ensemble approach suggests that the yeast network shows highly ordered dynamics.

The relation between accretion rate and jet power in X-ray luminous elliptical galaxies

Abstract: Using Chandra X-ray observations of nine nearby, X-ray luminous elliptical galaxies with good optical velocity dispersion measurements, we show that a tight correlation exists between the Bondi accretion rates calculated from the observed gas temperature and density profiles and estimated black hole masses, and the power emerging from these systems in relativistic jets. The jet powers, which are inferred from the energies and timescales required to inflate cavities observed in the surrounding X-ray emitting gas, can be related to the accretion rates using a power law model of the form log(PBondi/10 43 ergs 1 ) = A + B log(Pjet/10 43 ergs 1 ), with A = 0.65± 0.16 and B = 0.77± 0.20. Our results show that a significant fraction of the energy associated with the rest mass of material entering the Bondi accretion radius (2.2 +1.0 0.7 per cent, for Pjet = 10 43 ergs 1 ) eventually emerges in the relativistic jets. The data also hint that this fraction may rise slightly with increasing jet power. Our results have significant implications for studies of accretion, jet formation and galaxy formation. The observed tight correlation suggests that the Bondi formulae provide a reasonable description of the accretion process in these systems, despite the likely presence of magnetic pressure and angular momentum in the accreting gas. The similarity of the PBondi and Pjet values argues that a significant fraction of the matter entering the accretion radius flows down to regions close to the black holes, where the jets are presumably formed. The tight correlation between PBondi and Pjet also suggests that the accretion flows are approximately stable over timescales of a few million years. Our results show that the black hole ‘engines’ at the hearts of large elliptical galaxies and groups can feed back sufficient energy to stem cooling and s formation, leading naturally to the observed exponential cut off at the bright end of the galaxy luminosity function.

Distribution of non-telomeric sites of the (TTAGGG)n telomeric sequence in vertebrate chromosomes.

Abstract: The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.