Institution
University of Rennes
Education•Rennes, France•
About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.
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University of Texas Health Science Center at San Antonio1, Georgia Regents University2, Vancouver Island Health Authority3, University of Rennes4, University of Lorraine5, University of California, Davis6, Monash University7, Tulane University8, Uppsala University9, University of Gothenburg10, Merck & Co.11
TL;DR: The C-WORTHY trial as mentioned in this paper was a randomized, open-label phase 2 trial of grazoprevir plus elbasvir with or without ribavirin in patients with hepatitis C virus (HCV) genotype 1 infection with baseline characteristics of poor response.
269 citations
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TL;DR: A consistent age of about 2.5 AE has been obtained by the Rb-Sr and Sm-Nd whole-rock isochron methods, in agreement with the zircon U-Pb data.
Abstract: The granulite gneisses and their retrograded products of the Qianxi Group from eastern Hebei Province, China, have been investigated for their isotope and trace element geochemistry. A consistent age of about 2.5 AE has been obtained by the Rb-Sr and Sm-Nd whole-rock isochron methods, in agreement with the zircon U-Pb data (Pidgeon 1980; D.Y. Liu, unpubl.). Geochemical arguments from initial isotopic ratios (ISr and INd) and elemental distribution patterns have led us to conclude that this age of about 2.5 AE represents the time of granulite facies metamorphism, which must have followed closely the primary emplacement of their protoliths. Previous claims for early Archean ages (>3.5 AE) of these granulites are not substantiated. The mineral isotope systematics register an important thermal event at about 1.7 AE, roughly corresponding to the time of the widespread Luliang Orogeny (Ma and Wu 1981) or Chungtiao Movement (Huang 1978). The granulites of the Qianxi Group have diverse compositions ranging from ultrabasic through basic-intermediate to acid. Discriminant function calculations suggest that most analyzed samples have igneous parentage. Only a few show characteristics of metasedimentary rocks. The igneous protoliths apparently belong to two series — tholeiitic and calc-alkaline, with the latter dominating in abundance. The majority of the acid granulites have compositions corresponding to tonalite-granodiorite. Except for ultrabasic and metasedimentary rocks, all REE patterns are significantly fractionated with LREE enrichment. The degree of fractionation, as measured by the (La/Yb)N ratios, is most important in the acid granulites. These rocks often show positive Eu anomalies and HREE depletions that are typical of Archean TTG rocks (tonalitetrondhjemite-granodiorite). The existence of komatiites has been previously reported in this region. Although a few rocks have a major element chemistry similar to that for peridotitic komatiites, the lack of associated members in a komatiitic series and the scarcity of REE data have not confirmed the true komatiite occurrence in this region. Many Qianxi granulites are highly depleted in Rb relative to K and Sr. This preferential Rb depletion during granulite facies metamorphism has led to very high K/Rb and very low Rb/Sr ratios. The most comparable case is found in Lewisian granulites. Although the fractionated REE patterns of the basic granulites somewhat resemble those of continental flood basalts, the highly different abundances in other incompatible elements (Ti, Zr, and Ba) readily distinguish them from each other. Nevertheless, the LREE enriched patterns of the basic granulites may suggest an origin of their protoliths by partial melting of LREE-enriched mantle sources. On the other hand, the REE patterns of acid granulites suggest that their protoliths could be derived by partial melting of quartz eclogite, amphibolite or basic granulite. The close time relationship for a series of geologic events, namely, from initial melting of mantle peridotites, through fractional crystallisation of basaltic magmas, to granulite facies metamorphism, seems to occur in many granulite terrains. This relationship, together with the juxtaposition of lithologies of different origins and the exceptionally high pressure conditions (>10 Kb) can be best explained by crustal underplating combined with intracrustal thin-skinned thrusting and stacking of crustal slices. The “andesitic or island arc” model for the formation of the lower continental crust is not in good agreement with the present geochemical data.
268 citations
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TL;DR: This review identifies key research questions relevant to the Earth-surface processes community within the theme of mass and energy transfer across landscapes and offers guidance on how to identify the most appropriate topographic data type for the analysis of interest.
267 citations
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TL;DR: An interface that allows a user to accurately calculate a participant's centre of pressure (COP) and incorporate it into a virtual environment to create bespoke diagnostic or training programmes that exploit real-time visual feedback of current COP position is developed.
267 citations
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TL;DR: In vitro binding assays indicate that one sRNA encoded within a pathogenicity island is a trans-encoded antisense RNA regulating the expression of target genes at the posttranscriptional level, suggesting that they are involved in the regulation of staphylococcal virulence.
Abstract: Small RNA (sRNA) genes are expressed in all organisms, primarily as regulators of translation and message stability. We have developed comparative genomic approaches to identify sRNAs that are expressed by Staphylococcus aureus, the most common cause of hospital-acquired infections. This study represents an in-depth analysis of the RNome of a Gram-positive bacterium. A set of sRNAs candidates were identified in silico within intergenic regions, and their expression levels were monitored by using microarrays and confirmed by Northern blot hybridizations. Two sRNAs were also detected directly from purification and RNA sequence determination. In total, at least 12 sRNAs are expressed from the S. aureus genome, five from the core genome and seven from pathogenicity islands that confer virulence and antibiotic resistance. Three sRNAs are present in multiple (two to five) copies. For the sRNAs that are conserved throughout the bacterial phylogeny, their secondary structures were inferred by phylogenetic comparative methods. In vitro binding assays indicate that one sRNA encoded within a pathogenicity island is a trans-encoded antisense RNA regulating the expression of target genes at the posttranscriptional level. Some of these RNAs show large variations of expression among pathogenic strains, suggesting that they are involved in the regulation of staphylococcal virulence.
266 citations
Authors
Showing all 18470 results
Name | H-index | Papers | Citations |
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Philippe Froguel | 166 | 820 | 118816 |
Bart Staels | 152 | 824 | 86638 |
Yi Yang | 143 | 2456 | 92268 |
Geoffrey Burnstock | 141 | 1488 | 99525 |
Shahrokh F. Shariat | 118 | 1637 | 58900 |
Lutz Ackermann | 116 | 669 | 45066 |
Douglas R. MacFarlane | 110 | 864 | 54236 |
Elliott H. Lieb | 107 | 512 | 57920 |
Fu-Yuan Wu | 107 | 367 | 42039 |
Didier Sornette | 104 | 1295 | 44157 |
Stefan Hild | 103 | 452 | 68228 |
Pierre I. Karakiewicz | 101 | 1207 | 40072 |
Philippe Dubois | 101 | 1098 | 48086 |
François Bondu | 100 | 440 | 69284 |
Jean-Michel Savéant | 98 | 517 | 33518 |