University of Rennes

About: University of Rennes is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 18404 authors who have published 40374 publications receiving 995327 citations.

Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts

Abstract: Objectives: Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contr...

Seismic diagnostics for transport of angular momentum in stars. I. Rotational splittings from the pre-main sequence to the red-giant branch.

Abstract: Context. Rotational splittings are currently measured for several main sequence stars and a large number of red giants with the space mission Kepler. This will provide stringent constraints on rotation profiles. Aims: Our aim is to obtain seismic constraints on the internal transport and surface loss of the angular momentum of oscillating solar-like stars. To this end, we study the evolution of rotational splittings from the pre-main sequence to the red-giant branch for stochastically excited oscillation modes. Methods: We modified the evolutionary code CESAM2K to take rotationally induced transport in radiative zones into account. Linear rotational splittings were computed for a sequence of 1.3 Ms models. Rotation profiles were derived from our evolutionary models and eigenfunctions from linear adiabatic oscillation calculations. Results: We find that transport by meridional circulation and shear turbulence yields far too high a core rotation rate for red-giant models compared with recent seismic observations. We discuss several uncertainties in the physical description of stars that could have an impact on the rotation profiles. For instance, we find that the Goldreich-Schubert-Fricke instability does not extract enough angular momentum from the core to account for the discrepancy. In contrast, an increase of the horizontal turbulent viscosity by 2 orders of magnitude is able to significantly decrease the central rotation rate on the red-giant branch. Conclusions: Our results indicate that it is possible that the prescription for the horizontal turbulent viscosity largely underestimates its actual value or else a mechanism not included in current stellar models of low mass stars is needed to slow down the rotation in the radiative core of red-giant stars.

Restoration of Cenozoic deformation in Asia and the size of Greater India

Abstract: A long‐standing problem in the geological evolution of the India‐Asia collision zone is how and where convergence between India and Asia was accommodated since collision. Proposed collision ages vary from 65 to 35 Ma, although most data sets are consistent with collision being underway by 50 Ma. Plate reconstructions show that since 50 Ma ∼2400-3200 km (west to east) of India‐Asia convergence occurred, much more than the 450-900 km of documented Himalayan shortening. Current models therefore suggest that most post‐50 Ma convergence was accommodated north of the Indus‐Yarlung suture zone. We review kinematic data and construct an updated restoration of Cenozoic Asian deformation to test this assumption. We show that geologic studies have documented 600-750 km of N‐S Cenozoic shortening across, and north of, the Tibetan Plateau. The Pamir‐Hindu Kush region accommodated ∼1050 km of N‐S convergence. Geological evidence from Tibet is inconsistent with models that propose 750-1250 km of eastward extrusion of Indochina. Approximately 250 km of Indochinese extrusion from 30 to 20 Ma of Indochina suggested by SE Asia reconstructions can be reconciled by dextral transpression in eastern Tibet. We use our reconstruction to calculate the required size of Greater India as a function of collision age. Even with a 35 Ma collision age, the size of Greater India is 2-3 times larger than Himalayan shortening. For a 50 Ma collision, the size of Greater India from west to east is ∼1350-2600 km, consistent with robust paleomagnetic data from upper Cretaceous‐Paleocene Tethyan Himalayan strata. These estimates for the size of Greater India far exceed documented shortening in the Himalaya. We conclude that most of Greater India was consumed by subduction or underthrusting, without leaving a geological record that has been recognized at the surface.

Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion.

Abstract: Anti-Mullerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal functions. However, the possible extragonadal effects of AMH on the hypothalamic-pituitary-gonadal axis remain unexplored. Here we demonstrate that a significant subset of GnRH neurons both in mice and humans express the AMH receptor, and that AMH potently activates the GnRH neuron firing in mice. Combining in vivo and in vitro experiments, we show that AMH increases GnRH-dependent LH pulsatility and secretion, supporting a central action of AMH on GnRH neurons. Increased LH pulsatility is an important pathophysiological feature in many cases of polycystic ovary syndrome (PCOS), the most common cause of female infertility, in which circulating AMH levels are also often elevated. However, the origin of this dysregulation remains unknown. Our findings raise the intriguing hypothesis that AMH-dependent regulation of GnRH release could be involved in the pathophysiology of fertility and could hold therapeutic potential for treating PCOS.