Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Determination of the enantiomeric purity and the configuration of β-aminoalcohols using (R)-2-fluorophenylacetic acid (AFPA) and fluorine-19 NMR: application to β-blockers
TL;DR: In this paper, the enantiomeric purity and absolute configuration of β-aminoalcohols of type ArOCH2CH(OH)CH2NHR (R=iPr, tBu) were determined.
Journal ArticleDOI
Enantioselective synthesis of (R)-(−)-mevalonolactone via cyclic sulfate methodology
TL;DR: In this paper, an asymmetric synthesis of (R )-(−)-mevalonolactone is described using the Sharpless asymmetric dihydroxylation and the regioselective nucleophilic opening of a cyclic sulfate as key steps.
Journal ArticleDOI
Asymmetric [2+2] Cycloaddition Reaction Catalyzed by a Chiral Titanium Reagent
HayashiYujiro,NarasakaKoichi +1 more
TL;DR: Asymmetric cycloaddition reaction between 3-(2-acryloyl)-1,3-oxazolidin-2-one derivatives and 1,1-bis(methylthio)ethylene proceeds by the use of a catalytic amount of a chiral titanium reagent to give the corresponding cyclobutanes in high enantioselectivity as discussed by the authors.
Journal ArticleDOI
The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog.
TL;DR: The cerebroside glucosylceramide (23) was the next sphingolipid in this series to be synthesized in a highly homogeneous form and was demonstrated to be optically pure by a novel method utilizing Mosher's acid.
Journal ArticleDOI
Acetals as chiral auxillaries Part 4 (1)
TL;DR: In this article, a precursor of the California Red scale pheromone has been prepared using BF 3 reagents associated with tributylphosphine, which react stereoselectivity with chiral α,β-ethylenic acetals.
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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more