Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Journal ArticleDOI
Stereochemical control of yeast reductions: Synthesis of R-(+)-α-lipoic acid
TL;DR: The stereoselectivity of the reduction of alkyl 7-cyano-3-oxo-heptanoates with bakers' yeast was found to be influenced by the nature of the ester group.
Journal ArticleDOI
Chiral ligands containing heteroatoms. 6. 1-(2-Pyridylmethyl)pyrrolidine in the chiral catalysis of addition of diethylzinc to benzaldehyde.
TL;DR: In this article, a series of optically active pyridine ligands from proline derivatives has been developed for the enantioselective addition of dialkyl zinc compounds to aldehydes.
Journal ArticleDOI
Asymmetric allylborations of 3-decynal dicobalt hexacarbonyl: cobalt induced reversal of enantioselectivity and applications to highly diastereoselective intramolecular pauson-khand reactions
William R. Roush,J. C. Park +1 more
TL;DR: The enantioselective crotylborations of 3-decynal dicobalt hexacarbonyl (10) provide a very convenient route to stereochemically defined 1,6-enyne dICobalthexacaronyl complexes (12, 13 ) that undergo highly diasterelective intramolecular Pauson-Khand cyclizations to bicyclooctenones 14 and 15 (90% e.g. for 15 ).
Journal ArticleDOI
Synthesis of a chiral α-(aminooxy)arylacetic ester. II. A route through a chiral 2-hydroxy-2-phenylacetic acid derivative
Hisao Iwagami,Masanobu Yatagai,Masakazu Nakazawa,Haruo Orita,Yutaka Honda,Takashi Ohnuki,Toshihide Yukawa +6 more
TL;DR: In this paper, a simple and practical synthetic route was developed for the synthesis of a chiral α-(aminooxy) ester (S)-16, which is a synthetic intermediate for a potent antipseudomonal cephalosporin antibiotic M-14659.
Journal ArticleDOI
Enantioselective synthesis of arylmethoxyacetic acid derivatives
TL;DR: In this article, the preparation of several arylmethoxyacetic acids by a sequence of asymmetric dihydroxylation and further oxidation of the resulting glycol with TEMPO/NaClO/NClO2 is described.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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