Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Synthesis of medium ring ethers. Part 4. Stereoselective Claisen-mediated ring expansion as a route to homochiral disubstituted medium ring lactones
TL;DR: In this article, the selenoxides derived from the enantiomerically pure phenylselenomethyl-substituted cyclic acetals 4 and 8 proceeds stereospecifically to provide the homochiral 8- and 7-membered lactones 5 and 9 respectively.
Journal ArticleDOI
Optically Pure Isoproterenol Analogues With Side Chains Containing an Amide Bond: Synthesis and biological properties
Hans Peter Märki,Yvo Crameri,Rainer Eigenmann,Anna Krasso,Henri Ramuz,Karl Bernauer,M. Goodman,M. Goodman,Kenneth L. Melmon,Kenneth L. Melmon +9 more
TL;DR: Both ( 6R,2′R)-4a and (6R, 2′R-4b) show long lasting positive inotropic activity after intravenous as well as oral administration and are at least three times as potent as rac-isoproterenol.
Journal ArticleDOI
Conversion of chiral amino acids to enantiomerically pure α-methylamines
TL;DR: In this article, anantiomerically enriched α-methylamines are obtained in high yield by Raney nickel reduction of N-Boc-protected, amino acid-derived thioethers.
Journal ArticleDOI
Chiral organosilicon compounds in synthesis: Regio and stereoselective alkylation of a chiral α-silylcinnamyl carbanion
S. Lamothe,Tak Hang Chan +1 more
TL;DR: Good regio- and stereoselectivity can be obtained in the alkylation of chiral α-silylcinnamyl carbanion 8 in toluene as mentioned in this paper.
Journal ArticleDOI
Stereoselectivity of the carbonyl reduction of dolasetron in rats, dogs, and humans
J Dow,Christiane Berg +1 more
TL;DR: Enantioselectivity was not due to differences in the absorption, distribution, metabolism, or excretion of enantiomers, as iv or oral administration of rac-reduced dolasetron to rats and dogs lead to the recovery of essentially the same enantiomeric composition as the dose administered.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more