Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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A novel chiral auxiliary from chiral spiranes. cis,cis-(+)- and (–)-spiro[4.4]nonane-1,6-diol as chiral modifier in lithium aluminium hydride reduction of phenyl alkyl ketones
TL;DR: LiAlH4 reduction of phenyl alkyl ketones employing the hitherto unexplored chiral auxiliary cis,cis-(+)- and (−)-spiro[4.4]nonane-1,6-diol as chiral modifier gives the corresponding alcohol in 85-90% e.g. (enantiomeric excess).
Journal ArticleDOI
Conversion of Allylic Alcohols into Allylic Nitromethyl Compounds via a Palladium-Catalyzed Solvolysis: An Enantioselective Synthesis of an Advanced Carbocyclic Nucleoside Precursor1
Donald R. Deardorff,Kenneth A. Savin,Craig J. Justman,Zarir E. Karanjawala,James E. Sheppeck,David C. Hager,Nebil Aydin +6 more
TL;DR: A two-step reaction sequence to homoallylic nitro compounds from allylic alcohols is presented and serves as a centerpiece for the synthesis of an important carbocyclic nucleoside intermediate.
Journal ArticleDOI
Room-Temperature Metallation of 2-Substituted 1,3-Dithiane Derivatives and Subsequent Coupling with 2,3-Disubstituted Oxiranes
Mitsuaki Ide,Masaya Nakata +1 more
TL;DR: In this article, a mixture of mixed organometallic reagents, n-BuLi / Bu2Mg, was found to be an effective metallation reagent for 9 and the resulting anion reacted with 22 to afford the coupling product in good yield.
Journal ArticleDOI
Stereochemistry of Metabolism of Amphetamines: Use of (–)-α-Methoxy-α-(trifluoromethyl)phenylacetyl Chloride for GLC Resolution of Chiral Amines
TL;DR: The chiral acylating reagent was used in the determination of the enantiomeric composition of 2,5-dimethoxy-4- methylamphetamine excreted in rat urine after intraperitoneal drug administration and may be suitable for the resolution of amino acid enantiomers via the amide derivatives of the methyl esters.
Journal ArticleDOI
Polyphenols, Including the New Peapolyphenols A−C, from Pea Root Exudates Stimulate Orobanche foetida Seed Germination
Antonio Evidente,Alessio Cimmino,Mónica Fernández-Aparicio,Anna Andolfi,Diego Rubiales,Andrea Motta +5 more
TL;DR: Three new polyphenols, named peapolyphenols A-C, together with an already well-known polyphenol and a chalcone (1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphensyl)-1-propanone and 1,3-disubstituted propenone) were found to strongly stimulate Orobanche and Phelipanche species seed germination.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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