Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Journal ArticleDOI
(−)-Sparteine-mediated stereoselective intramolecular carbolithiation of alkynes
TL;DR: The asymmetric deprotonation mediated by the chiral base s-butyllithium/(−)-sparteine of 4-substituted 5-hexynyl carbamates allowed the synthesis of enantioenriched carbanionic pairs which undergo a regioselective 5-exo-dig ring closure with the triple bond acting as an internal electrophile as discussed by the authors.
Journal ArticleDOI
Identification of the pheromone of the Comstock mealybug
B. A. Bierl-Leonhardt,Daniel S. Moreno,Meyer Schwarz,Harold S. Forster,J. R. Plimmer,E. David DeVilbiss +5 more
TL;DR: This is the first pheromone identified from the mealybug family and its norterpene (9-carbon) skeleton is uncommon among insect pheromes, and was synthesized and shown to be highly attractive in field bioassay at concentrations as low as 0.2 μg per trap.
Journal ArticleDOI
Atropisomeric benzamides and naphthamides as chiral auxiliaries
TL;DR: In this paper, atropisomeric compounds whose chirality resides in a rotationally restricted aryl-CONR2 bond are employed as chiral auxiliaries.
PatentDOI
Structural requirements of histone deacetylase inhibitors: C4-modified SAHA analogs display dual HDAC6/HDAC8 selectivity
TL;DR: The nonselective HDAC inhibitor SAHA was modified at the C4 position of the linker to explore activity and selectivity, and several C4-modified SAHA analogs exhibited dual HDAC6/8 selectivity.
Journal ArticleDOI
A formal synthesis of the callipeltoside aglycone.
TL;DR: In this paper, a synthesis of the macrocyclic core structure of callipeltoside A and a C9 epimer has been achieved by applications of chiral vinylzinc or Kishi−Nozaki−Hiyama (K−N−H) additions, Roskamp homologations, and acylketene or intramolecular K−N −H macrolactonizations as key bond-forming steps.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more