Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Inhibition of cytoplasmic aspartate aminotransferase from porcine heart by R and S isomers of aminooxysuccinate and hydrazinosuccinate.
TL;DR: D- and L-aminooxysuccinate were synthesized and evaluated as inhibitors of cytoplasmic aspartate aminotransferase from porcine heart and showed good geometry for hydrogen bond and ion pair formation and aldimine double bond formed by the L-isomers is not coplanar with the pyridoxal phosphate ring in accordance with the spectral properties of the inhibitor complexes.
Journal ArticleDOI
Total synthesis of R-(+)-patulolide A and R-(−)-patulolide B: The macrolides isolated from Penicillium urticae mutant
TL;DR: The title compounds (2E, 11R)-4-oxo-2-dodecen-11-olide, 1 and (2Z, 11 R)-4oxo 2-deconvoxel-decen-eleven-oxide, 2 were synthesised in optically pure forms from a nitroalkane synthon involving a chiral resolution step using goat liver lipase.
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Synthesis of cyclic ethers via 5-exo iodonium assisted epoxide ring expansion.
TL;DR: In this paper, the transannular cyclization of (Z,Z)-1-hydroxy-cyclonona-2,6-diene by iodonium assisted oxirane ring expansion was studied.
Journal ArticleDOI
Synthesis and antimycobacterial activity of 2,1'-dihydropyridomycins.
TL;DR: The 2R isomer 2 shows only 4-fold lower anti-Mtb activity than 1, indicating that the enol ester moiety in the natural product is not critical for its biological activity.
Journal ArticleDOI
Enantioselective addition of chirally modified methyltitanium reagents to aromatic aldehydes
TL;DR: N-Sulfonylated derivatives of norephedrine are excellent ligands for chirally modified methyltitanium reagents, the latter reacting enantioselectively with aromatic aldehydes (ee ~ 90%) to form R-configurated carbinols as discussed by the authors.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more