Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
About:
This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
Citations
More filters
Journal ArticleDOI
An Insight into the Active Site of Pseudomonas Fluorecens (P. cepacia) Lipase to Define the Stereochemical Demand for the Transesterification in Organic Solvents
TL;DR: The Pseudomonas fluorescens lipase-catalyzed transesterification of 2-methyl alkanols 1 and the 2-substituted oxiranemethanols 2 with vinyl acetate in organic solvents has been studied and the results discussed in terms of steric and electronic demand within the recently postulated models of the lipase active site.
Journal ArticleDOI
An efficient synthesis of (R)-3-hydroxytetradecanoic acid
TL;DR: In this paper, a short, efficient synthesis of (R)-3-hydroxytetradecanoic acid, a key component of bacterial endotoxins, using (R)oxirane acetic acid ethyl ester as the source of chirality is described.
Journal ArticleDOI
Convergent Synthesis of Fluorescence Labeled Solamin
TL;DR: In this paper, the convergent synthesis of dansyl-labeled solamin, an antitumor Annonaceous acetogenin, has been achieved by assembling the carbon skeleton from three fragments: the THF ring fragment, the fluorescent fragment and the γ-lactone fragment by asymmetric alkynylation.
Journal ArticleDOI
Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid L-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid.
Zheng Xiang,Lei Wang +1 more
TL;DR: An efficient six-step synthesis of L-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid (L-Anap), a genetically encodable and polarity-sensitive fluorescent UAA, has been developed and takes advantage of a high-yield and enantiospecific Fukuyama-Mitsunobu reaction as the key transformation.
Journal ArticleDOI
Enantioselective diastereospecific synthesis of anti-α-alkyl-β-hydroxy esters through cuprate opening of glycidic esters
Johann Mulzer,Ortrud Lammer +1 more
TL;DR: A diastereospecific chain elongation of the aldehydes 1 of anti-α-alkyl-β-hydroxy esters 2 via the intermediates 4–7 is described and 2 may be obtained with >90% ee in either enantiomer.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more