Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Tellurium in Organic Synthesis. Preparation of Z-Vinylic Cuprates from Z-Vinylic Tellurides and Their Reaction with Enones and Epoxides
TL;DR: In this article, the double-bond configuration of the original vinylic telluride was preserved, and the resulting Z-vinylic higher-order cyanocuprates react with enones to give the corresponding 1,4-addition products in good yields.
Journal ArticleDOI
Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxes
Oliver J. McConnell,Alvin C. Bach,Carl J. Balibar,Neal Byrne,Yanxuan Cai,Guy T. Carter,Michael Chlenov,Li Di,Kristi Fan,Igor Goljer,Yanan He,Don Herold,Michael Z. Kagan,Edward H. Kerns,Frank E. Koehn,Christina M. Kraml,Vasilios Marathias,Brian L. Marquez,Leonard A. McDonald,Lisa Nogle,Christopher J. Petucci,Gerhard Schlingmann,Gregory J. Tawa,Mark Tischler,R. Thomas Williamson,Alan G. Sutherland,William L. Watts,Mairead Young,Mei-Yi Zhang,Yingru Zhang,Dahui Zhou,Douglas M. Ho +31 more
TL;DR: Based on the experiences of one pharmaceutical company, a summary of the establishment of a Chiral Technology toolbox, including the implementation of known tools as well as the design, development, and implementation of new Chiral technology tools, is provided.
Journal ArticleDOI
NMR spectroscopic detection of chirality and enantiopurity in referenced systems without formation of diastereomers
Jan Labuta,Shinsuke Ishihara,Tomáš Šikorský,Zdeněk Futera,Zdeněk Futera,Atsuomi Shundo,Atsuomi Shundo,Lenka Hanyková,Jaroslav V. Burda,Katsuhiko Ariga,Jonathan P. Hill +10 more
TL;DR: An effective method of enantiomeric excess determination using a symmetrical achiral molecule as the resolving agent, which is based on the complexation with analyte (in the fast exchange regime) without the formation of diastereomers.
Journal ArticleDOI
Enantioselective Total Synthesis of (−)-Chlorothricolide via the Tandem Inter- and Intramolecular Diels−Alder Reaction of a Hexaenoate Intermediate
TL;DR: An enantioselective total synthesis of (−)-chlorothricolide (1) has been completed via a route involving the tandem inter- and intramolecular Diels−Alder (IMDA) reaction of hexaenoate 19 and the chiral dienophile (R)-12 as mentioned in this paper.
Journal ArticleDOI
Incorporation of 2-C-Methyl-d-erythritol, a Putative Isoprenoid Precursor in the Mevalonate-Independent Pathway, into Ubiquinone and Menaquinone of Escherichia coli
TL;DR: Incorporation of deuterium labelled 2-C-methyl-d-erythritol into isoprenoid side-chains of ubiquinone and menaquinone from Escherichia coli strongly supports the proposed intermediate role of this branched sugar derivative in the mevalonate independent pathway for isopranoid biosynthesis via glyceraldehyde 3-phosphate and pyruvate.
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