Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Diastereoselective fluorination of chiral imide enolates using N-fluoro-O-benzenedisulfonimide (NFOBS)
Franklin A. Davis,W. Han +1 more
TL;DR: In this article, the diastereoselective fluorination of chiral imide enolates with NFOBS was used to obtain β-fluoro alcohols.
Journal ArticleDOI
Stereoselective total synthesis of etnangien and etnangien methyl ester.
TL;DR: The expedient and flexible strategy of the etnangiens should be amenable to designed analogues of these RNA-polymerase inhibitors, thus enabling further exploration of the promising biological potential of these macrolide antibiotics.
Journal ArticleDOI
Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2
George Kokotos,Stavroula Kotsovolou,David A. Six,Violetta Constantinou-Kokotou,Christopher C. Beltzner,Edward A. Dennis +5 more
TL;DR: Among the compounds tested, a long-chain 2-oxoamide containing L-gamma-norleucine was the most potent inhibitor, causing a 50% decrease in GIVA PLA(2) activity at 0.009 mole fraction.
Journal ArticleDOI
The Reaction of Active Zinc with Organic Bromides
TL;DR: In this paper, the electron transfer (ET) is the rate-determining step of the reaction in the case of aryl halide radical anions as intermediates.
Journal ArticleDOI
Synthesis of Zaragozic Acid A/Squalestatin S1
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Eddy W. Yue,Eddy W. Yue,Susan La Greca,Susan La Greca,Alan Nadin,Alan Nadin,Zhen Yang,Zhen Yang,James E. Leresche,James E. Leresche,Tatsuo Tsuri,Tatsuo Tsuri,Yoshimitsu Naniwa,Yoshimitsu Naniwa,Francesco De Riccardis,Francesco De Riccardis +17 more
TL;DR: In this article, the tricarboxylic acid core portion is assembled in three key steps: 1) Stille coupling to establish the carbon framework, 2) enanti-lective dihydroxylation to introduce the absolute stereochemistry, and 3) diastereoselective dithiane addition to complete the required carbon-oxygen connectivity.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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