Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Ligand-based improvement of enantioselectivity in the catalytic asymmetric dihydroxylation of dialkyl substituted olefins
TL;DR: In this article, a high level of asymmetric induction was achieved in the asymmetric dihydroxylation of dialkyl substituted olefins using 9-O-aryldihydroquinidines as ligands.
Journal ArticleDOI
The first syntheses of the 1-oxo-2-oxa-5-azaspiro[3.4]octane ring system found in oxazolomycin.
TL;DR: L-Proline was utilized to prepare an optically active 1-oxo-2-oxa-5-azaspiro[3.4]octane for the first time and the synthesis of the racemic system, using a tandem aldol-lactonization reaction, is described.
Journal ArticleDOI
Enantioselektive Verseifung der Diacetate von 2‐Nitro‐1,3‐diolen mit Schweineleber‐Esterase und Herstellung enantiomerenreiner Derivate von 2‐Nitro‐allylalkoholen (chirale Verknüpfungsreagenzien)
TL;DR: The reproducible enantioselective saponification of open-chain and cyclic diacetates of meso-2-nitro-1,3-propanediols with pig-liver esterase (PLE) gives monoacetates (see 4c,l3c) of > 95% enantiomeric excess as mentioned in this paper.
Journal ArticleDOI
Carbamate-directed stereoselective hydrogenation and kinetic resolution of N-protected α-(α-aminoalkyl)acrylates
Masatoshi Takagi,Keiji Yamamoto +1 more
TL;DR: A series of raceme methyl α-[α-(methoxycarbonylamino)alkyl]acrylates ( 1a-e ) were hydrogenated using a variety ofRh(I) cationic complexes containing diphosphines and a chiral [Ru(OAc) 2 (S)-BIHAP] (BINAP = 2,2′-bis(diphenylphosphino)-1,1′-dinaphthyl) as catalyst precursors to give preferentially the threo isomers ( 2
Journal ArticleDOI
3-Hydroxyglutarate and β,γ-epoxy esters as substrates for pig liver esterase (PLE) and α-chymotrypsin
TL;DR: In this article, the pH dependence of α-chymotrypsin-catalyzed hydrolysis of dimethyl 3-hydroxyglutarate (3) has been studied.
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