Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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A new approach to functionalized cyclobutanes: Stereoselective synthesis of the enantiomers of grandisol and fraganol
TL;DR: In this paper, enantiomerically enriched (+)-grandisol and (+)-fraganol were synthesized using as the key step a new stereoselective synthesis of cyclobutanes fused to γ-lactones by a stereochemically-controlled intramolecular alkylation of α-benzenesulfonyl-γ lactones.
Journal ArticleDOI
Lipase-catalyzed selective benzoylation of 1,2-diols with vinyl benzoate in organic solvents
TL;DR: This work has studied the MML-catalyzed benzoylation that proceeds with high regioselectivity and moderate enantioselectivities, whereas in the dibenzoylation reaction activity of MML and stereoselectiveness of the enzymatic process is strongly influenced by steric factors.
Journal ArticleDOI
Total synthesis of cerebrosides: (2S, 3R, 4E)-1-O-β-d-galactopyranosyl-N-(2′R and 2′S)-2′-hydroxytetracosanoylsphingenine
TL;DR: In this article, total synthesisation of both (2S, 3R, 4E)-1-O-β-d -galactopyranosyl-N-(2′R)-2′-hydroxytetracosanoylsphingenine 23 and the (2′S) stereoisomer were performed in an unambiguous way by employing either (2 S, 3 R, 4 E)-N-( 2′R), 2′-(tert-butyl-diphenylsilyloxy)tetrasan
Journal ArticleDOI
Synthetic studies toward verrucosidin: determination of the absolute configuration
Jin K. Cha,R.J. Cooke +1 more
TL;DR: The tetrahydrofuran portion of verrucosidin was synthesized in an enantiomerically pure form via the stereoselective osmylation of the chiral hydroxy diene ester 5 as a key step as discussed by the authors.
Journal ArticleDOI
Saponaceolides: Differential cytotoxicity and enantioselective synthesis of the right-hand lactone moiety
TL;DR: In this article, the enantioselective synthesis of the right-hand lactone moiety 5 of saponaceolide B, 2 was described, and the mean graph profiles of 5 do not match the characteristic patterns of differential cytotoxicity of SCL in the NCI human diseaseoriented tumor screening panel, pointing out the need of the entire SCL structure for maintaining the specificity and potency of the antitumor activity.
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