Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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A convenient asymmetric synthesis of anti-β-amino alcohols: an X-ray crystallographic study of (4R)-2,2-dimethyl-4-[(2S)-(diphenylmethyleneamino)-(1S)-hydroxy-3-buten-1-yl]-1,3-dioxolane
TL;DR: In this paper, anti-β-Diphenylmethyleneamino alcohols have been produced with high relative and absolute sterocontrol in a one-pot process; subsequent deprotection gave antiβ-hydroxy amines in good yield.
Journal ArticleDOI
The absolute configuration of the mushroom metabolites involutin and chamonixin
TL;DR: The absolute configurations of the cyclopentanoid fungal metabolites involutin (1) and chamonixin (2) have been determined by application of the high-field 1H NMR variant of Mosher's method as discussed by the authors.
Journal ArticleDOI
Asymmetric synthesis of conformationally constrained 4-hydroxyprolines and their applications to the formal synthesis of (+)-epibatidine
TL;DR: In this article, the synthesis of enantiomerically pure (1 S, 3 S, 4 R )-3-hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylic acids was described.
Journal ArticleDOI
β-elimination of protected aldono-1,4-lactones as a general approach to the synthesis of 2-keto-3-deoxyaldonic acids containing four to six carbon atoms
Gerrit Limberg,Joachim Thiem +1 more
TL;DR: In this article, the β-elimination of protected enol 1,4-lactones is used for the synthesis of short-chain 2-keto-3-deoxyaldonic acids.
Journal ArticleDOI
New enantioselective approach to α-allokainoids by Michael addition to chiral 4-substituted 2,3-didehydroprolinate
TL;DR: In this article, the α-Allokainoids were obtained by hydrolysis of the corresponding Michael adducts resulting from the addition of diethyl malonate to chiral N-urethane protected ethyl 4-benzyl-2,3-didehydroprolinates 9 and 13 respectively.
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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more