Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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A simple method for the microscale preparation of mosher's acid chloride
Dale E. Ward,Chung K. Rhee +1 more
TL;DR: In this article, Mosher's acid is treated with oxalyl chloride in the presence of DMF in hexane, which is suitable for use without further purification and is amenable to microscale.
Journal ArticleDOI
Asymmetric deprotonation of prochiral ketones using chiral lithium amide bases
TL;DR: In this article, a number of chiral secondary amines have been prepared and used as precursors to the corresponding chiral lithium amide bases, and the results with 4- tert -butylcyclohexanone are in disagreement with an earlier literature report, giving products of lower enantiomeric excess but higher optical rotation.
Journal ArticleDOI
Optically active ruthenium porphyrins: chiral recognition and asymmetric catalysis
Gérard Simonneaux,Paul Le Maux +1 more
TL;DR: In this paper, the current applications of ruthenium porphyrins in stoichiometric and catalytic asymmetric reactions are reported Chiral recognition of racemic phosphines, isocyanides and amino esters has been studied by 1H-NMR Experimental investigations of the oxidation mechanism of racemia phosphines and amino isters are described.
Journal ArticleDOI
Asymmetric halogenation of chiral imide enolates. A general approach to the synthesis of enantiomerically pure α-amino acids.
TL;DR: The chiral N-acyl oxazolidones 2, as the derived dibutyl boron enolates, have been demonstrated to undergo diastereoselective bromination and subsequent azide displacement to give the α-azido carboximides 4a (5 cases) as mentioned in this paper.
Journal ArticleDOI
Multicomponent Hantzsch cyclocondensation as a route to highly functionalized 2- and 4-dihydropyridylalanines, 2- and 4-pyridylalanines, and their N-oxides: preparation via a polymer-assisted solution-phase approach
TL;DR: An improved and efficient entry to highly functionalized β-(2-pyridyl)- and β-(4-polygonal)-alanines and the corresponding 1,4-dihydro and N-oxide derivatives has been developed by one-pot thermal Hantzsch-type cyclocondensation of aldehyde-ketoester-enamine systems in which one of the reagents (aldehyde or ketoester) was carrying the unmasked but protected chiral glycinyl moiety as mentioned in this paper.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more